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• W2019436391 startingPage "2453" @default.
• W2019436391 abstract "The specification of the intricate neuronal assemblies that characterize the forebrain is not well understood. The ventral spinal cord is specified through a concentration gradient of Sonic hedgehog (Shh) protein secreted by the notochord. Shh is expressed also in the forebrain neuroepithelium (neural Shh) and the underlying notochord and prechordal plate. Neural Shh is essential for the development of the prethalamus (ventral thalamus), but its effects on the thalamus (dorsal thalamus) are still unclear. We hypothesized that neural Shh would act on a previously regionalized dorsal diencephalic region to promote the emergence of specific thalamic nuclear and histological traits. To find out, we generated a conditional mouse mutant line specifically lacking Shh expression in the diencephalic neuroepithelium. We show that the transcription factor Gbx2, required for thalamic development downstream Shh , is expressed in our mutant in a restricted thalamic region and is necessary and sufficient for the differentiation of the medial and intralaminar thalamic nuclei. In the rest of the thalamus, neural Shh is required to promote neuronal aggregation into nuclei as well as axonal extension. In this way, the individual thalamic nuclei show differential dependence on Shh , Gbx2 , or both for their differentiation. Additionally, Gbx2 is required for the survival of thalamic neurons." @default.
• W2019436391 created "2016-06-24" @default.
• W2019436391 creator A5028338266 @default.
• W2019436391 creator A5036687246 @default.
• W2019436391 creator A5040723573 @default.
• W2019436391 creator A5075239982 @default.
• W2019436391 date "2009-02-25" @default.
• W2019436391 modified "2023-10-16" @default.
• W2019436391 title "The Role of Sonic Hedgehog of Neural Origin in Thalamic Differentiation in the Mouse" @default.
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• W2019436391 doi "https://doi.org/10.1523/jneurosci.4524-08.2009" @default.
• W2019436391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6666239" @default.
• W2019436391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19244520" @default.
• W2019436391 hasPublicationYear "2009" @default.
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