FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019436589> ?p ?o ?g. }

• W2019436589 endingPage "750" @default.
• W2019436589 startingPage "737" @default.
• W2019436589 abstract "[Met]Enkephalin-Arg6-Gly7-Leu8 is an endogenous opioid peptide, first isolated from the bovine adrenal medulla. Because this octapeptide is specifically contained in the amino acid sequence of preproenkephalin A but not in other opioid precursors like preproopiomelanocortin or preproenkephalin B, [Met]enkephalin-Arg6-Gly7-Leu8 has been regarded as a specific marker for preproenkephalin A and its derivatives. In this study, we examined the occurrence and origin of [Met]enkephalin-Arg6-Gly7-Leu8-immunoreactive nerves in the guinea-pig and rat lung by immunohistochemical techniques, using a specific antiserum against this peptide. In addition, we investigated the possible co-existence of [Met]enkephalin-Arg6-Gly7-Leu8 and vasoactive intestinal peptide immunoreactivity in neuronal elements of the respiratory tract. In both species, [Met]enkephalin-Arg6-Gly7-Leu8 immunoreactivity was localized in nerve fibers chiefly distributed to the trachea and major bronchi, where they were prevalent in smooth muscle bundles, in the lamina propria, around airway glands, and in the walls of pulmonary vessels, but were absent in airway epithelium. Slight differences in the distribution pattern of immunoreactive nerve fibers were noted between the two species: immunoreactive nerve fibers in the smooth muscle bundles were much more abundant in guinea-pigs than in rats, while those in the mucous glands were richer in rats than in guinea-pigs. Neither chemical sympathectomy by 6-hydroxydopamine, nor chemical sensory denervation by capsaicin, changed the density or distribution of [Met]enkephalin-Arg6-Gly7-Leu8-immunoreactive nerve fibers in the airway, suggesting an intrinsic source for these nerve fibers. Colchicine injection into the tracheal wall, to promote the accumulation of neuropeptides in nerve cell bodies, led to the visualization of [Met]enkephalin-Arg6-Gly7-Leu8 immunoreactivity in some neuronal cell bodies within airway ganglia. Immunostaining for [Met]enkephalin-Arg6-Gly7-Leu8 and for vasoactive intestinal polypeptide on serial adjacent sections of airway ganglia obtained from colchicine-treated tracheae, demonstrated the co-existence of these immunoreactivities in a population of nerve cell bodies in these ganglia. The immunohistochemical localization of immunoreactive [Met]enkephalin-Arg6-Gly7-Leu8 in nerve elements in guinea-pig and rat lungs provides a morphological basis for the possibility that preproenkephalin A-related opioid peptides may have a neuromodulatory role in mammalian airways and pulmonary vessels." @default.
• W2019436589 created "2016-06-24" @default.
• W2019436589 creator A5009901046 @default.
• W2019436589 creator A5029930183 @default.
• W2019436589 creator A5072457191 @default.
• W2019436589 date "1990-01-01" @default.
• W2019436589 modified "2023-10-14" @default.
• W2019436589 title "[Met]enkephalin-arg6-gly7-leu8-immunoreactive nerves in guinea-pig and rat lungs: Distribution, origin, and co-existence with vasoactive intestinal polypeptide immunoreactivity" @default.
• W2019436589 cites W1414355486 @default.
• W2019436589 cites W1529166175 @default.
• W2019436589 cites W1965860693 @default.
• W2019436589 cites W1968206565 @default.
• W2019436589 cites W1970388909 @default.
• W2019436589 cites W1972444986 @default.
• W2019436589 cites W1974782548 @default.
• W2019436589 cites W1976700309 @default.
• W2019436589 cites W1978238621 @default.
• W2019436589 cites W1983650616 @default.
• W2019436589 cites W1984885291 @default.
• W2019436589 cites W1985130776 @default.
• W2019436589 cites W1993841252 @default.
• W2019436589 cites W1995174089 @default.
• W2019436589 cites W2000127122 @default.
• W2019436589 cites W2000140354 @default.
• W2019436589 cites W2001134858 @default.
• W2019436589 cites W2003063301 @default.
• W2019436589 cites W2003172853 @default.
• W2019436589 cites W2004612241 @default.
• W2019436589 cites W2009033426 @default.
• W2019436589 cites W2010051841 @default.
• W2019436589 cites W2016919586 @default.
• W2019436589 cites W2026313282 @default.
• W2019436589 cites W2027618345 @default.
• W2019436589 cites W2031376908 @default.
• W2019436589 cites W2033814096 @default.
• W2019436589 cites W2034228917 @default.
• W2019436589 cites W2037175122 @default.
• W2019436589 cites W2040494904 @default.
• W2019436589 cites W2043708408 @default.
• W2019436589 cites W2044526972 @default.
• W2019436589 cites W2044798577 @default.
• W2019436589 cites W2045881081 @default.
• W2019436589 cites W2046827175 @default.
• W2019436589 cites W2047869895 @default.
• W2019436589 cites W2047920764 @default.
• W2019436589 cites W2048795599 @default.
• W2019436589 cites W2049144674 @default.
• W2019436589 cites W2050451695 @default.
• W2019436589 cites W2050569442 @default.
• W2019436589 cites W2053243081 @default.
• W2019436589 cites W2059462636 @default.
• W2019436589 cites W2068155648 @default.
• W2019436589 cites W2070624459 @default.
• W2019436589 cites W2070958561 @default.
• W2019436589 cites W2072229549 @default.
• W2019436589 cites W2079183484 @default.
• W2019436589 cites W2080376817 @default.
• W2019436589 cites W2080722824 @default.
• W2019436589 cites W2081910239 @default.
• W2019436589 cites W2082681259 @default.
• W2019436589 cites W2083574273 @default.
• W2019436589 cites W2088259380 @default.
• W2019436589 cites W2089018293 @default.
• W2019436589 cites W2102620584 @default.
• W2019436589 cites W2127830630 @default.
• W2019436589 cites W2134677848 @default.
• W2019436589 cites W2167955309 @default.
• W2019436589 cites W2404778832 @default.
• W2019436589 cites W2433622487 @default.
• W2019436589 cites W2766738060 @default.
• W2019436589 cites W2767370069 @default.
• W2019436589 cites W2768053426 @default.
• W2019436589 cites W2771772891 @default.
• W2019436589 cites W2886202317 @default.
• W2019436589 cites W4211008542 @default.
• W2019436589 cites W4300059956 @default.
• W2019436589 cites W4323284209 @default.
• W2019436589 doi "https://doi.org/10.1016/0306-4522(90)90016-w" @default.
• W2019436589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1700333" @default.
• W2019436589 hasPublicationYear "1990" @default.
• W2019436589 type Work @default.
• W2019436589 sameAs 2019436589 @default.
• W2019436589 citedByCount "25" @default.
• W2019436589 countsByYear W20194365892017 @default.
• W2019436589 crossrefType "journal-article" @default.
• W2019436589 hasAuthorship W2019436589A5009901046 @default.
• W2019436589 hasAuthorship W2019436589A5029930183 @default.
• W2019436589 hasAuthorship W2019436589A5072457191 @default.
• W2019436589 hasConcept C105702510 @default.
• W2019436589 hasConcept C118303440 @default.
• W2019436589 hasConcept C126322002 @default.
• W2019436589 hasConcept C134018914 @default.
• W2019436589 hasConcept C142724271 @default.
• W2019436589 hasConcept C170493617 @default.
• W2019436589 hasConcept C185592680 @default.
• W2019436589 hasConcept C2777803847 @default.
• W2019436589 hasConcept C2778815084 @default.
• W2019436589 hasConcept C2781063702 @default.

• next