Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019436866> ?p ?o ?g. }
- W2019436866 endingPage "1793" @default.
- W2019436866 startingPage "1780" @default.
- W2019436866 abstract "In the last decades, homology modeling has become a popular tool to access theoretical three-dimensional (3D) structures of molecular targets. So far several 3D models of proteins have been built by this technique and used in a great diversity of structural biology studies. But are those models consistent enough with experimental structures to make this technique an effective and reliable tool for drug discovery? Here we present, briefly, the fundamentals and current state-of-the-art of the homology modeling techniques used to build 3D structures of molecular targets, which experimental structures are not available in databases, and list some of the more important works, using this technique, available in literature today. In many cases those studies have afforded successful models for the drug design of more selective agonists/antagonists to the molecular targets in focus and guided promising experimental works, proving that, when the appropriate templates are available, useful models can be built using some of the several software available today for this purpose. Limitations of the experimental techniques used to solve 3D structures allied to constant improvements in the homology modeling software will maintain the need for theoretical models, establishing the homology modeling as a fundamental tool for the drug discovery." @default.
- W2019436866 created "2016-06-24" @default.
- W2019436866 creator A5046413341 @default.
- W2019436866 date "2014-11-06" @default.
- W2019436866 modified "2023-10-03" @default.
- W2019436866 title "Homology modeling: an important tool for the drug discovery" @default.
- W2019436866 cites W1481137597 @default.
- W2019436866 cites W1520470614 @default.
- W2019436866 cites W1524940515 @default.
- W2019436866 cites W1544386129 @default.
- W2019436866 cites W1546896179 @default.
- W2019436866 cites W1563102372 @default.
- W2019436866 cites W1575824270 @default.
- W2019436866 cites W1606011614 @default.
- W2019436866 cites W1963735212 @default.
- W2019436866 cites W1966041739 @default.
- W2019436866 cites W1974664442 @default.
- W2019436866 cites W1976554063 @default.
- W2019436866 cites W1978106273 @default.
- W2019436866 cites W1978304263 @default.
- W2019436866 cites W1981860349 @default.
- W2019436866 cites W1982722489 @default.
- W2019436866 cites W1984207607 @default.
- W2019436866 cites W1984879522 @default.
- W2019436866 cites W1986191025 @default.
- W2019436866 cites W1987187865 @default.
- W2019436866 cites W1988564488 @default.
- W2019436866 cites W1992167175 @default.
- W2019436866 cites W1992820326 @default.
- W2019436866 cites W1992842793 @default.
- W2019436866 cites W1993418211 @default.
- W2019436866 cites W1995089537 @default.
- W2019436866 cites W1995705468 @default.
- W2019436866 cites W1998676514 @default.
- W2019436866 cites W2000812882 @default.
- W2019436866 cites W2002736499 @default.
- W2019436866 cites W2002996251 @default.
- W2019436866 cites W2003194288 @default.
- W2019436866 cites W2006197769 @default.
- W2019436866 cites W2007697641 @default.
- W2019436866 cites W2010506933 @default.
- W2019436866 cites W2010677996 @default.
- W2019436866 cites W2010806889 @default.
- W2019436866 cites W2013083986 @default.
- W2019436866 cites W2013184299 @default.
- W2019436866 cites W2013238066 @default.
- W2019436866 cites W2015292449 @default.
- W2019436866 cites W2016140206 @default.
- W2019436866 cites W2017736729 @default.
- W2019436866 cites W2021663918 @default.
- W2019436866 cites W2022012830 @default.
- W2019436866 cites W2024473428 @default.
- W2019436866 cites W2024755629 @default.
- W2019436866 cites W2025673019 @default.
- W2019436866 cites W2028590160 @default.
- W2019436866 cites W2028725729 @default.
- W2019436866 cites W2033496784 @default.
- W2019436866 cites W2034266737 @default.
- W2019436866 cites W2035399289 @default.
- W2019436866 cites W2035487460 @default.
- W2019436866 cites W2038117444 @default.
- W2019436866 cites W2045303196 @default.
- W2019436866 cites W2046392396 @default.
- W2019436866 cites W2047444442 @default.
- W2019436866 cites W2050903719 @default.
- W2019436866 cites W2051653737 @default.
- W2019436866 cites W2051831487 @default.
- W2019436866 cites W2055043387 @default.
- W2019436866 cites W2059333155 @default.
- W2019436866 cites W2059351220 @default.
- W2019436866 cites W2060145604 @default.
- W2019436866 cites W2061031649 @default.
- W2019436866 cites W2062246909 @default.
- W2019436866 cites W2064587798 @default.
- W2019436866 cites W2068487566 @default.
- W2019436866 cites W2072526722 @default.
- W2019436866 cites W2073743133 @default.
- W2019436866 cites W2078569751 @default.
- W2019436866 cites W2086012629 @default.
- W2019436866 cites W2088917076 @default.
- W2019436866 cites W2088933990 @default.
- W2019436866 cites W2090096265 @default.
- W2019436866 cites W2090852407 @default.
- W2019436866 cites W2090939777 @default.
- W2019436866 cites W2091528698 @default.
- W2019436866 cites W2095324960 @default.
- W2019436866 cites W2095542571 @default.
- W2019436866 cites W2097546936 @default.
- W2019436866 cites W2099628648 @default.
- W2019436866 cites W2100517022 @default.
- W2019436866 cites W2100729071 @default.
- W2019436866 cites W2103425480 @default.
- W2019436866 cites W2103522079 @default.
- W2019436866 cites W2104812418 @default.
- W2019436866 cites W2105146210 @default.
- W2019436866 cites W2105291717 @default.
- W2019436866 cites W2115727110 @default.
- W2019436866 cites W2116275717 @default.