FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019436999> ?p ?o ?g. }

• W2019436999 endingPage "7592" @default.
• W2019436999 startingPage "7588" @default.
• W2019436999 abstract "Enterokinase is a protease of the intestinal brush border that specifically cleaves the acidic propeptide from trypsinogen to yield active trypsin. This cleavage initiates a cascade of proteolytic reactions leading to the activation of many pancreatic zymogens. The full-length cDNA sequence for bovine enterokinase and partial cDNA sequence for human enterokinase were determined. The deduced amino acid sequences indicate that active two-chain enterokinase is derived from a single-chain precursor. Membrane association may be mediated by a potential signal-anchor sequence near the amino terminus. The amino terminus of bovine enterokinase also meets the known sequence requirements for protein N-myristoylation. The amino-terminal heavy chain contains domains that are homologous to segments of the low density lipoprotein receptor, complement components C1r and C1s, the macrophage scavenger receptor, and a recently described motif shared by the metalloprotease meprin and the Xenopus A5 neuronal recognition protein. The carboxyl-terminal light chain is homologous to the trypsin-like serine proteases. Thus, enterokinase is a mosaic protein with a complex evolutionary history. The amino acid sequence surrounding the amino terminus of the enterokinase light chain is ITPK-IVGG (human) or VSPK-IVGG (bovine), suggesting that single-chain enterokinase is activated by an unidentified trypsin-like protease that cleaves the indicated Lys-Ile bond. Therefore, enterokinase may not be the first enzyme of the intestinal digestive hydrolase cascade. The specificity of enterokinase for the DDDDK-I sequence of trypsinogen may be explained by complementary basic-amino acid residues clustered in potential S2-S5 subsites." @default.
• W2019436999 created "2016-06-24" @default.
• W2019436999 creator A5009170192 @default.
• W2019436999 creator A5040531464 @default.
• W2019436999 creator A5044510198 @default.
• W2019436999 creator A5047842892 @default.
• W2019436999 creator A5061354837 @default.
• W2019436999 date "1994-08-02" @default.
• W2019436999 modified "2023-10-04" @default.
• W2019436999 title "Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains." @default.
• W2019436999 cites W1540882827 @default.
• W2019436999 cites W1549885152 @default.
• W2019436999 cites W1551626360 @default.
• W2019436999 cites W1555742321 @default.
• W2019436999 cites W1558814513 @default.
• W2019436999 cites W1580027256 @default.
• W2019436999 cites W1595443666 @default.
• W2019436999 cites W1596637018 @default.
• W2019436999 cites W1600871831 @default.
• W2019436999 cites W1864169613 @default.
• W2019436999 cites W1898735964 @default.
• W2019436999 cites W1993158258 @default.
• W2019436999 cites W1996241166 @default.
• W2019436999 cites W1998336764 @default.
• W2019436999 cites W2000083793 @default.
• W2019436999 cites W2008751497 @default.
• W2019436999 cites W2014669590 @default.
• W2019436999 cites W2017906988 @default.
• W2019436999 cites W2018082148 @default.
• W2019436999 cites W2018289835 @default.
• W2019436999 cites W2024637178 @default.
• W2019436999 cites W2030958084 @default.
• W2019436999 cites W2042681117 @default.
• W2019436999 cites W2048877959 @default.
• W2019436999 cites W2049661143 @default.
• W2019436999 cites W2049831508 @default.
• W2019436999 cites W2057957477 @default.
• W2019436999 cites W2062999041 @default.
• W2019436999 cites W2064244952 @default.
• W2019436999 cites W2066551266 @default.
• W2019436999 cites W2069472625 @default.
• W2019436999 cites W2070018377 @default.
• W2019436999 cites W2094728080 @default.
• W2019436999 cites W2100837269 @default.
• W2019436999 cites W2108388593 @default.
• W2019436999 cites W2117006120 @default.
• W2019436999 cites W2134812217 @default.
• W2019436999 cites W2138270253 @default.
• W2019436999 cites W2301338283 @default.
• W2019436999 cites W7002981 @default.
• W2019436999 doi "https://doi.org/10.1073/pnas.91.16.7588" @default.
• W2019436999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44447" @default.
• W2019436999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8052624" @default.
• W2019436999 hasPublicationYear "1994" @default.
• W2019436999 type Work @default.
• W2019436999 sameAs 2019436999 @default.
• W2019436999 citedByCount "158" @default.
• W2019436999 countsByYear W20194369992012 @default.
• W2019436999 countsByYear W20194369992013 @default.
• W2019436999 countsByYear W20194369992014 @default.
• W2019436999 countsByYear W20194369992015 @default.
• W2019436999 countsByYear W20194369992016 @default.
• W2019436999 countsByYear W20194369992017 @default.
• W2019436999 countsByYear W20194369992018 @default.
• W2019436999 countsByYear W20194369992020 @default.
• W2019436999 countsByYear W20194369992021 @default.
• W2019436999 countsByYear W20194369992022 @default.
• W2019436999 countsByYear W20194369992023 @default.
• W2019436999 crossrefType "journal-article" @default.
• W2019436999 hasAuthorship W2019436999A5009170192 @default.
• W2019436999 hasAuthorship W2019436999A5040531464 @default.
• W2019436999 hasAuthorship W2019436999A5044510198 @default.
• W2019436999 hasAuthorship W2019436999A5047842892 @default.
• W2019436999 hasAuthorship W2019436999A5061354837 @default.
• W2019436999 hasBestOaLocation W20194369991 @default.
• W2019436999 hasConcept C104317684 @default.
• W2019436999 hasConcept C123894998 @default.
• W2019436999 hasConcept C145508813 @default.
• W2019436999 hasConcept C153911025 @default.
• W2019436999 hasConcept C167625842 @default.
• W2019436999 hasConcept C181199279 @default.
• W2019436999 hasConcept C182220744 @default.
• W2019436999 hasConcept C185592680 @default.
• W2019436999 hasConcept C187882448 @default.
• W2019436999 hasConcept C2776714187 @default.
• W2019436999 hasConcept C2777807008 @default.
• W2019436999 hasConcept C2780340462 @default.
• W2019436999 hasConcept C2781286802 @default.
• W2019436999 hasConcept C40767141 @default.
• W2019436999 hasConcept C515207424 @default.
• W2019436999 hasConcept C55493867 @default.
• W2019436999 hasConcept C86803240 @default.
• W2019436999 hasConceptScore W2019436999C104317684 @default.
• W2019436999 hasConceptScore W2019436999C123894998 @default.
• W2019436999 hasConceptScore W2019436999C145508813 @default.
• W2019436999 hasConceptScore W2019436999C153911025 @default.
• W2019436999 hasConceptScore W2019436999C167625842 @default.
• W2019436999 hasConceptScore W2019436999C181199279 @default.

• next