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- W2019437854 abstract "Although executive functions have been associated with autonomic regulatory capacity in healthy adults, there appear to be no reports of these relations in adults with schizophrenia to date. We tested whether baseline autonomic regulation was associated with performance on the Wisconsin Card Sorting Test (WCST) in a group of 42 stable community outpatients with schizophrenia. Patients exhibited faster resting heart rates and lower respiratory sinus arrhythmia (RSA) than age-matched controls, consistent with previous research. Patients also completed relatively few WCST categories and made many perseverative errors, replicating prior studies. Within the patient group, relatively better WCST performance was associated with slower resting heart rate and higher RSA, suggesting that inefficient executive and autonomic functioning in schizophrenia may be linked. WCST performance and autonomic regulatory capacity were further reduced in a subset of patients receiving clozapine, but relations between WCST performance and autonomic regulatory parameters did not differ from those of other patients. Findings extend the neurovisceral integration model of autonomic regulation to adults with schizophrenia and attest to the reliability of the model." @default.
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- W2019437854 date "2008-06-01" @default.
- W2019437854 modified "2023-09-23" @default.
- W2019437854 title "CATECHOL-O-METHYLTRANSFERASEVAL158MET GENOTYPE MODULATES HIPPOCAMPAL ACTIVITY IN SCHIZOPHRENIC PATIENTS PERFORMING AN ATTENTIONAL TASK" @default.
- W2019437854 doi "https://doi.org/10.1016/s0920-9964(08)70276-7" @default.
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