FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019441679> ?p ?o ?g. }

• W2019441679 endingPage "1654" @default.
• W2019441679 startingPage "1647" @default.
• W2019441679 abstract "Abstract: Human neuronal brain cultures established from 12- and 14-week-old fetuses synthesize and secrete urokinase-type plasminogen activator (uPA) and limited amounts of tissue-type plasminogen activator (tPA). These cells also produce and secrete the endothelial cell-type PA inhibitor (PAII), which forms sodium dodecyl sulfate-stable tPA/PAI-I complexes in the culture medium. Immunocytochemistry shows a predominant localization of uPA, tPA, and PAI-1 in neuronal cells, with only a very weak positivity detectable in the few glial cells present in these cultures. The protein kinase C (PKC) activator 12-0-tetradecanoylphorbol 13-ac-etate (TPA) stimulates the synthesis of both uPA and PAI-I, resulting in a final increase in the plasmin-generating capacity of neuronal cell cultures. No significant effect is observed, however, when cells are treated with the TPA analogue 4a-phorbol 12,13-didecanoate, which is inactive as a PKC inducer, or with the neurotrophic polypeptide basic fibroblast growth factor. These data represent the first characterization of the plasmin-generating system in human fetal brain neurons and suggest a role for PKC in the modulation of uPA and PAI-I synthesis." @default.
• W2019441679 created "2016-06-24" @default.
• W2019441679 creator A5005942566 @default.
• W2019441679 creator A5028999880 @default.
• W2019441679 creator A5056536189 @default.
• W2019441679 creator A5067546225 @default.
• W2019441679 creator A5080210324 @default.
• W2019441679 date "1990-11-01" @default.
• W2019441679 modified "2023-09-28" @default.
• W2019441679 title "Synthesis of Urokinase-Type Plasminogen Activator and of Type- 1 Plasminogen Activator Inhibitor in Neuronal Cultures of Human Fetal Brain: Stimulation by Phorbol Ester" @default.
• W2019441679 cites W1499469957 @default.
• W2019441679 cites W1531884888 @default.
• W2019441679 cites W1534398269 @default.
• W2019441679 cites W1590437917 @default.
• W2019441679 cites W1591865377 @default.
• W2019441679 cites W1594758412 @default.
• W2019441679 cites W1966182982 @default.
• W2019441679 cites W1977311938 @default.
• W2019441679 cites W1991337902 @default.
• W2019441679 cites W1992129124 @default.
• W2019441679 cites W2001692359 @default.
• W2019441679 cites W2002471001 @default.
• W2019441679 cites W2003452235 @default.
• W2019441679 cites W2024935441 @default.
• W2019441679 cites W2027399729 @default.
• W2019441679 cites W2034299466 @default.
• W2019441679 cites W2046143615 @default.
• W2019441679 cites W2047309494 @default.
• W2019441679 cites W2049042095 @default.
• W2019441679 cites W2049661577 @default.
• W2019441679 cites W2053991417 @default.
• W2019441679 cites W2055431675 @default.
• W2019441679 cites W2055809729 @default.
• W2019441679 cites W2071092961 @default.
• W2019441679 cites W2077283393 @default.
• W2019441679 cites W2082584924 @default.
• W2019441679 cites W2083368047 @default.
• W2019441679 cites W2092157425 @default.
• W2019441679 cites W2101657207 @default.
• W2019441679 cites W2151920226 @default.
• W2019441679 cites W2152025158 @default.
• W2019441679 cites W23122061 @default.
• W2019441679 cites W4244633958 @default.
• W2019441679 doi "https://doi.org/10.1111/j.1471-4159.1990.tb04951.x" @default.
• W2019441679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2213017" @default.
• W2019441679 hasPublicationYear "1990" @default.
• W2019441679 type Work @default.
• W2019441679 sameAs 2019441679 @default.
• W2019441679 citedByCount "31" @default.
• W2019441679 countsByYear W20194416792016 @default.
• W2019441679 countsByYear W20194416792018 @default.
• W2019441679 countsByYear W20194416792023 @default.
• W2019441679 crossrefType "journal-article" @default.
• W2019441679 hasAuthorship W2019441679A5005942566 @default.
• W2019441679 hasAuthorship W2019441679A5028999880 @default.
• W2019441679 hasAuthorship W2019441679A5056536189 @default.
• W2019441679 hasAuthorship W2019441679A5067546225 @default.
• W2019441679 hasAuthorship W2019441679A5080210324 @default.
• W2019441679 hasConcept C104317684 @default.
• W2019441679 hasConcept C126322002 @default.
• W2019441679 hasConcept C134018914 @default.
• W2019441679 hasConcept C153911025 @default.
• W2019441679 hasConcept C170493617 @default.
• W2019441679 hasConcept C181199279 @default.
• W2019441679 hasConcept C184235292 @default.
• W2019441679 hasConcept C195794163 @default.
• W2019441679 hasConcept C2775960820 @default.
• W2019441679 hasConcept C2776892390 @default.
• W2019441679 hasConcept C2777587049 @default.
• W2019441679 hasConcept C2779679481 @default.
• W2019441679 hasConcept C2780884517 @default.
• W2019441679 hasConcept C2781071845 @default.
• W2019441679 hasConcept C35866371 @default.
• W2019441679 hasConcept C529278444 @default.
• W2019441679 hasConcept C54355233 @default.
• W2019441679 hasConcept C55493867 @default.
• W2019441679 hasConcept C71924100 @default.
• W2019441679 hasConcept C81885089 @default.
• W2019441679 hasConcept C86803240 @default.
• W2019441679 hasConcept C88045685 @default.
• W2019441679 hasConcept C95444343 @default.
• W2019441679 hasConceptScore W2019441679C104317684 @default.
• W2019441679 hasConceptScore W2019441679C126322002 @default.
• W2019441679 hasConceptScore W2019441679C134018914 @default.
• W2019441679 hasConceptScore W2019441679C153911025 @default.
• W2019441679 hasConceptScore W2019441679C170493617 @default.
• W2019441679 hasConceptScore W2019441679C181199279 @default.
• W2019441679 hasConceptScore W2019441679C184235292 @default.
• W2019441679 hasConceptScore W2019441679C195794163 @default.
• W2019441679 hasConceptScore W2019441679C2775960820 @default.
• W2019441679 hasConceptScore W2019441679C2776892390 @default.
• W2019441679 hasConceptScore W2019441679C2777587049 @default.
• W2019441679 hasConceptScore W2019441679C2779679481 @default.
• W2019441679 hasConceptScore W2019441679C2780884517 @default.
• W2019441679 hasConceptScore W2019441679C2781071845 @default.
• W2019441679 hasConceptScore W2019441679C35866371 @default.
• W2019441679 hasConceptScore W2019441679C529278444 @default.
• W2019441679 hasConceptScore W2019441679C54355233 @default.

• next