Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019450751> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2019450751 endingPage "248" @default.
- W2019450751 startingPage "243" @default.
- W2019450751 abstract "The possible interaction between antiestrogens (tamoxifen, clomiphene and nafoxidine) and bepridil, a known Na+-Ca2+ exchange blocker, in the regulation of cell growth was investigated using U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cells as model cellular systems. The co-treatment of bepridil with antiestrogens significantly enhanced the antiestrogen-induced inhibition of the tumor cell growth. This bepridil-induced enhanced growth inhibition was significantly blocked by the addition of BAPTA/AM, an intracellular Ca2+ chelator, implying that increased free intracellular Ca2+ concentration may be involved in these actions. Other Na+-Ca2+ exchange blockers such as nickel and benzamil, also significantly potentiated the antiestrogen-induced inhibition of the tumor cell growth. Taken together, the blockade of Na+-Ca2+ exchange mechanism by these drugs may cause prolongation of increased intracellular Ca2+ concentration, in turn leading to these potentiated growth inhibitions of the tumor cells. These results suggest that the combined treatment with bepridil and antiestrogens may be a potential strategy for chemotherapy of brain tumors." @default.
- W2019450751 created "2016-06-24" @default.
- W2019450751 creator A5075027403 @default.
- W2019450751 creator A5086997980 @default.
- W2019450751 date "1996-12-01" @default.
- W2019450751 modified "2023-10-18" @default.
- W2019450751 title "Bepridil enhances in vitro antitumor activity of antiestrogens in human brain tumor cells" @default.
- W2019450751 cites W1539752474 @default.
- W2019450751 cites W1598082982 @default.
- W2019450751 cites W1754065147 @default.
- W2019450751 cites W1967960255 @default.
- W2019450751 cites W1969284128 @default.
- W2019450751 cites W1995371547 @default.
- W2019450751 cites W1995552235 @default.
- W2019450751 cites W2015970432 @default.
- W2019450751 cites W2018089591 @default.
- W2019450751 cites W2022128427 @default.
- W2019450751 cites W2025376585 @default.
- W2019450751 cites W2025818427 @default.
- W2019450751 cites W2067401118 @default.
- W2019450751 cites W2080698860 @default.
- W2019450751 cites W2094557223 @default.
- W2019450751 cites W2137911312 @default.
- W2019450751 cites W2223026985 @default.
- W2019450751 cites W2277606692 @default.
- W2019450751 cites W2397619464 @default.
- W2019450751 cites W2418279482 @default.
- W2019450751 doi "https://doi.org/10.1016/s0304-3835(96)04518-1" @default.
- W2019450751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9018108" @default.
- W2019450751 hasPublicationYear "1996" @default.
- W2019450751 type Work @default.
- W2019450751 sameAs 2019450751 @default.
- W2019450751 citedByCount "5" @default.
- W2019450751 countsByYear W20194507512017 @default.
- W2019450751 countsByYear W20194507512019 @default.
- W2019450751 crossrefType "journal-article" @default.
- W2019450751 hasAuthorship W2019450751A5075027403 @default.
- W2019450751 hasAuthorship W2019450751A5086997980 @default.
- W2019450751 hasConcept C121608353 @default.
- W2019450751 hasConcept C126322002 @default.
- W2019450751 hasConcept C134018914 @default.
- W2019450751 hasConcept C178790620 @default.
- W2019450751 hasConcept C185592680 @default.
- W2019450751 hasConcept C2776067312 @default.
- W2019450751 hasConcept C2777022698 @default.
- W2019450751 hasConcept C2777176818 @default.
- W2019450751 hasConcept C2778937662 @default.
- W2019450751 hasConcept C2779707156 @default.
- W2019450751 hasConcept C2780019300 @default.
- W2019450751 hasConcept C519063684 @default.
- W2019450751 hasConcept C530470458 @default.
- W2019450751 hasConcept C55493867 @default.
- W2019450751 hasConcept C62112901 @default.
- W2019450751 hasConcept C71924100 @default.
- W2019450751 hasConcept C79879829 @default.
- W2019450751 hasConcept C86803240 @default.
- W2019450751 hasConcept C98274493 @default.
- W2019450751 hasConceptScore W2019450751C121608353 @default.
- W2019450751 hasConceptScore W2019450751C126322002 @default.
- W2019450751 hasConceptScore W2019450751C134018914 @default.
- W2019450751 hasConceptScore W2019450751C178790620 @default.
- W2019450751 hasConceptScore W2019450751C185592680 @default.
- W2019450751 hasConceptScore W2019450751C2776067312 @default.
- W2019450751 hasConceptScore W2019450751C2777022698 @default.
- W2019450751 hasConceptScore W2019450751C2777176818 @default.
- W2019450751 hasConceptScore W2019450751C2778937662 @default.
- W2019450751 hasConceptScore W2019450751C2779707156 @default.
- W2019450751 hasConceptScore W2019450751C2780019300 @default.
- W2019450751 hasConceptScore W2019450751C519063684 @default.
- W2019450751 hasConceptScore W2019450751C530470458 @default.
- W2019450751 hasConceptScore W2019450751C55493867 @default.
- W2019450751 hasConceptScore W2019450751C62112901 @default.
- W2019450751 hasConceptScore W2019450751C71924100 @default.
- W2019450751 hasConceptScore W2019450751C79879829 @default.
- W2019450751 hasConceptScore W2019450751C86803240 @default.
- W2019450751 hasConceptScore W2019450751C98274493 @default.
- W2019450751 hasIssue "1-2" @default.
- W2019450751 hasLocation W20194507511 @default.
- W2019450751 hasLocation W20194507512 @default.
- W2019450751 hasOpenAccess W2019450751 @default.
- W2019450751 hasPrimaryLocation W20194507511 @default.
- W2019450751 hasRelatedWork W1494012992 @default.
- W2019450751 hasRelatedWork W1502667688 @default.
- W2019450751 hasRelatedWork W1929970298 @default.
- W2019450751 hasRelatedWork W1970061594 @default.
- W2019450751 hasRelatedWork W1995901867 @default.
- W2019450751 hasRelatedWork W2015692861 @default.
- W2019450751 hasRelatedWork W2035274793 @default.
- W2019450751 hasRelatedWork W2062688712 @default.
- W2019450751 hasRelatedWork W2090294875 @default.
- W2019450751 hasRelatedWork W2926335606 @default.
- W2019450751 hasVolume "110" @default.
- W2019450751 isParatext "false" @default.
- W2019450751 isRetracted "false" @default.
- W2019450751 magId "2019450751" @default.
- W2019450751 workType "article" @default.