Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019454646> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2019454646 endingPage "33" @default.
- W2019454646 startingPage "25" @default.
- W2019454646 abstract "Three different bradycardic agents, alinidine, AQ-A39 and UL-FS49 increase the intrinsic cycle length of the isolated SA node preparation of the rabbit. This increase is mainly caused by a decrease in rate of diastolic depolarization. One of these agents, alinidine, was used to study the underlying ionic mechanism of the decrease in the diastolic depolarization rate in isolated cells and small cell clusters of the rabbit SA node. In these preparations alinidine slowed down the rate of spontaneous activity at higher concentrations (80 μM). At lower concentrations (10 μM) the decrease in rate of spontaneous activity was variable, but injection of a hyperpolarizing current slowed the spontaneous rate more in the presence of alinidine, indicating an increase in membrane resistance. In voltage clamp experiments we found that the main effect of alinidine was a block of the hyperpolarization activated current ij. The block was potential dependent and was maximal in the potential range in which diastolic depolarization occurs. These results are discussed in relation to previous findings of others." @default.
- W2019454646 created "2016-06-24" @default.
- W2019454646 creator A5004356998 @default.
- W2019454646 creator A5023740415 @default.
- W2019454646 creator A5029658732 @default.
- W2019454646 creator A5041324147 @default.
- W2019454646 creator A5048522751 @default.
- W2019454646 creator A5055132455 @default.
- W2019454646 date "1987-12-02" @default.
- W2019454646 modified "2023-10-16" @default.
- W2019454646 title "Alinidine as a model of the mode of action of specific bradycardic agents on SA node activity" @default.
- W2019454646 doi "https://doi.org/10.1093/eurheartj/8.suppl_l.25" @default.
- W2019454646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3451880" @default.
- W2019454646 hasPublicationYear "1987" @default.
- W2019454646 type Work @default.
- W2019454646 sameAs 2019454646 @default.
- W2019454646 citedByCount "10" @default.
- W2019454646 crossrefType "journal-article" @default.
- W2019454646 hasAuthorship W2019454646A5004356998 @default.
- W2019454646 hasAuthorship W2019454646A5023740415 @default.
- W2019454646 hasAuthorship W2019454646A5029658732 @default.
- W2019454646 hasAuthorship W2019454646A5041324147 @default.
- W2019454646 hasAuthorship W2019454646A5048522751 @default.
- W2019454646 hasAuthorship W2019454646A5055132455 @default.
- W2019454646 hasConcept C12554922 @default.
- W2019454646 hasConcept C126322002 @default.
- W2019454646 hasConcept C131453863 @default.
- W2019454646 hasConcept C164705383 @default.
- W2019454646 hasConcept C181911157 @default.
- W2019454646 hasConcept C185592680 @default.
- W2019454646 hasConcept C197270303 @default.
- W2019454646 hasConcept C2777953023 @default.
- W2019454646 hasConcept C2778542873 @default.
- W2019454646 hasConcept C4141045 @default.
- W2019454646 hasConcept C42219234 @default.
- W2019454646 hasConcept C57900726 @default.
- W2019454646 hasConcept C66974803 @default.
- W2019454646 hasConcept C71240020 @default.
- W2019454646 hasConcept C71924100 @default.
- W2019454646 hasConcept C84393581 @default.
- W2019454646 hasConcept C86803240 @default.
- W2019454646 hasConcept C98274493 @default.
- W2019454646 hasConceptScore W2019454646C12554922 @default.
- W2019454646 hasConceptScore W2019454646C126322002 @default.
- W2019454646 hasConceptScore W2019454646C131453863 @default.
- W2019454646 hasConceptScore W2019454646C164705383 @default.
- W2019454646 hasConceptScore W2019454646C181911157 @default.
- W2019454646 hasConceptScore W2019454646C185592680 @default.
- W2019454646 hasConceptScore W2019454646C197270303 @default.
- W2019454646 hasConceptScore W2019454646C2777953023 @default.
- W2019454646 hasConceptScore W2019454646C2778542873 @default.
- W2019454646 hasConceptScore W2019454646C4141045 @default.
- W2019454646 hasConceptScore W2019454646C42219234 @default.
- W2019454646 hasConceptScore W2019454646C57900726 @default.
- W2019454646 hasConceptScore W2019454646C66974803 @default.
- W2019454646 hasConceptScore W2019454646C71240020 @default.
- W2019454646 hasConceptScore W2019454646C71924100 @default.
- W2019454646 hasConceptScore W2019454646C84393581 @default.
- W2019454646 hasConceptScore W2019454646C86803240 @default.
- W2019454646 hasConceptScore W2019454646C98274493 @default.
- W2019454646 hasIssue "suppl L" @default.
- W2019454646 hasLocation W20194546461 @default.
- W2019454646 hasLocation W20194546462 @default.
- W2019454646 hasOpenAccess W2019454646 @default.
- W2019454646 hasPrimaryLocation W20194546461 @default.
- W2019454646 hasRelatedWork W1964624075 @default.
- W2019454646 hasRelatedWork W1988351503 @default.
- W2019454646 hasRelatedWork W2060662231 @default.
- W2019454646 hasRelatedWork W2074086821 @default.
- W2019454646 hasRelatedWork W2076763519 @default.
- W2019454646 hasRelatedWork W2335532758 @default.
- W2019454646 hasRelatedWork W2355308038 @default.
- W2019454646 hasRelatedWork W2378890859 @default.
- W2019454646 hasRelatedWork W2414906792 @default.
- W2019454646 hasRelatedWork W2429251272 @default.
- W2019454646 hasVolume "8" @default.
- W2019454646 isParatext "false" @default.
- W2019454646 isRetracted "false" @default.
- W2019454646 magId "2019454646" @default.
- W2019454646 workType "article" @default.