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- W2019457056 abstract "Purpose/Objective: Intravascular brachytherapy after angioplasty for coronary and peripheral arteries has been shown to have the potential to reduce the rate of restenosis in both animal experiments and some clinical trials. The purpose of this study was to develop a new intravascular brachytherapy system including the originally designed balloon catheter and afterloading brachytherapy system. Materials/Methods: The balloon catheter for intravascular brachytherapy should ideally have the following properties: (1) able to center a radiation source to deliver a homogenous dose to the vascular surface, (2) able to maintain distal arterial blood flow, and (3) sufficient flexibility to allow introduction into the target. A balloon catheter that satisfied the above requirements, and an afterloading system that could deliver a 192-Iridium source were developed. A 192-Iridium source was made of several 192-Iridium seeds that were placed serially to facilitate flexibility. Then we assessed the following issues: (1) the performance and safety of these devices using an artificial phantom vessel and animal experiments, (2) dose distribution around the 192-Iridium source when implanted at varying intervals (0.5 mm, 1 mm and 2 mm) between seeds using thermoluminescent (TL) sheets and (3) flexibility of the source using catheters with various radii. Results: The new balloon catheter (Fig 1) had multiple serially-arranged hemispherical projections. In the initial study using the dummy vessel, the ability to center and maintain the distal flow were confirmed. In animal experiments using canines, the centering effect and the distal flow were also demonstrated fluoroscopically. The new afterloader was manually-operated type, and had two loading systems for an actual 192-Iridium source and a dummy source. The insertion distance of the source was measurable by an encoder, and storage of the source was electrically detectable. In point of dose distribution, the interval of each 192-Iridium seed was more appropriate in 0.5 mm and 1 mm than in 2 mm but the source was difficult to advance into a bent catheter when the interval was 0.5 mm. Therefore, we selected 1 mm for the interval between seeds. Conclusions: The new catheter system for intravascular brachytherapy seems promising. However, further study is necessary for clinical application." @default.
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- W2019457056 date "2002-10-01" @default.
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- W2019457056 title "Development of a new intravascular brachytherapy system to prevent restenosis after percutaneous transluminal angioplasty" @default.
- W2019457056 doi "https://doi.org/10.1016/s0360-3016(02)03579-4" @default.
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