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• W2019460870 abstract "The effects of a fat and glutamine‐free orally administered total parenteral nutrition (TPN) solution on intestinal mucosal mass, morphology, barrier function, and cecal bacterial population levels were measured in CD‐1 mice. Ileal mucosal protein content decreased by 63% ( p < 0.01) in the oral TPN‐fed mice, although they gained weight on this diet. These TPN‐fed mice also exhibited changes in mucosal structure and the normal ecology of their cecal microflora was disrupted leading to overgrowth with Gram‐negative enteric bacilli. These changes in intestinal mucosal mass, morphology, and gut bacterial ecology were associated with an increased incidence of bacterial translocation (BT) (TPN group 70% BT us control group 15% BT: p < 0.01). The administration of cellulose fiber or kaolin (bulk‐forming agents), but not of citrus‐pectin (a fully‐fermentable, nonresidue fiber) reduced the incidence of BT in the TPN‐fed mice to control levels. The beneficial effects of these bulk‐forming agents appeared to be due to their ability to prevent TPN‐induced disruption of the intestinal microflora and alterations in intestinal morphology, even though they did not prevent ileal mucosal protein levels from decreasing. These results suggest that the administration of bulk forming agents will prevent the loss of intestinal barrier function against luminal bacteria that occurs in mice fed an oral TPN solution. ( Journal of Parenteral and Enteral Nutrition 14 :442–447, 1990)" @default.
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• W2019460870 date "1990-09-01" @default.
• W2019460870 modified "2023-09-30" @default.
• W2019460870 title "Bulk Prevents Bacterial Translocation Induced by the Oral Administration of Total Parenteral Nutrition Solution" @default.
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• W2019460870 doi "https://doi.org/10.1177/0148607190014005442" @default.
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