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• W2019464529 startingPage "23543" @default.
• W2019464529 abstract "Pathogenic Yersinia spp. translocate the effectors YopT, YopE, and YopO/YpkA into target cells to inactivate Rho family GTP-binding proteins and block immune responses. Some Yersinia spp. also secrete the Rho protein activator cytotoxic necrotizing factor-Y (CNF-Y), but it has been unclear how the bacteria may benefit from Rho protein activation. We show here that CNF-Y increases Yop translocation in Yersinia enterocolitica-infected cells up to 5-fold. CNF-Y strongly activated RhoA and also delayed in time Rac1 and Cdc42, but when individually expressed, constitutively active mutants of Rac1, but not of RhoA, increased Yop translocation. Consistently, knock-out or knockdown of Rac1 but not of RhoA, -B, or -C inhibited Yersinia effector translocation in CNF-Y-treated and control cells. Activation or knockdown of Cdc42 also affected Yop translocation but much less efficiently than Rac. The increase in Yop translocation induced by CNF-Y was essentially independent of the presence of YopE, YopT, or YopO in the infecting Yersinia strain, indicating that none of the Yops reported to inhibit translocation could reverse the CNF-Y effect. In summary, the CNF-Y activity of Yersinia strongly enhances Yop translocation through activation of Rac." @default.
• W2019464529 created "2016-06-24" @default.
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• W2019464529 date "2013-08-01" @default.
• W2019464529 modified "2023-10-16" @default.
• W2019464529 title "Cytotoxic Necrotizing Factor-Y Boosts Yersinia Effector Translocation by Activating Rac Protein" @default.
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• W2019464529 doi "https://doi.org/10.1074/jbc.m112.448662" @default.
• W2019464529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3949328" @default.
• W2019464529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23803609" @default.
• W2019464529 hasPublicationYear "2013" @default.
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