Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019467507> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2019467507 endingPage "511" @default.
- W2019467507 startingPage "508" @default.
- W2019467507 abstract "The receptor tyrosine kinase c-Kit plays crucial roles in lymphocyte development but there is little information on the molecular circuitry enforcing c-Kit expression. In addition to growth factors, Notch signaling is essential for T cell development. In this issue of the European Journal of Immunology, evidence is provided for an interesting link between c-Kit and Notch. The primary ‘test subjects’ were a Pax5-deficient ‘pro-B cell’ line, blocked in its B cell potential, and its non-mutated counterpart, a bone marrow-derived early progenitor with lymphoid and myeloid potential (EPLM). Similar to common lymphoid progenitors, EPLM have a ‘B cell-biased’ potential, yet show multipotency under appropriate conditions. Following Notch signaling, c-Kit expression was very rapidly upregulated and the development into T cells was found to be c-Kit-dependent. In the absence of Notch signals, c-Kit expression remained low. Development into non-T cell fates (NK or myeloid) was found to be c-Kit-independent. It remains to be determined whether c-Kit is a ‘direct’ target of the Notch signal transduction pathway; however, these findings, together with those of others, strongly suggest that Notch can contribute to the proper cytokine receptor pattern required for commitment and expansion of early intrathymic progenitors. See accompanying article: http://dx.doi.org/10.1002/eji.200535760" @default.
- W2019467507 created "2016-06-24" @default.
- W2019467507 creator A5003632224 @default.
- W2019467507 date "2006-03-01" @default.
- W2019467507 modified "2023-09-27" @default.
- W2019467507 title "Making a Notch in the lymphocyte kit" @default.
- W2019467507 cites W1484947470 @default.
- W2019467507 cites W1552274890 @default.
- W2019467507 cites W1965051817 @default.
- W2019467507 cites W1965989057 @default.
- W2019467507 cites W1973637933 @default.
- W2019467507 cites W1981611424 @default.
- W2019467507 cites W1988855837 @default.
- W2019467507 cites W1997936907 @default.
- W2019467507 cites W2014458327 @default.
- W2019467507 cites W2028735719 @default.
- W2019467507 cites W2052631664 @default.
- W2019467507 cites W2058858066 @default.
- W2019467507 cites W2062356998 @default.
- W2019467507 cites W2067143990 @default.
- W2019467507 cites W2069407272 @default.
- W2019467507 cites W2093643928 @default.
- W2019467507 cites W2095638063 @default.
- W2019467507 cites W2123410322 @default.
- W2019467507 cites W2124172350 @default.
- W2019467507 cites W2134766010 @default.
- W2019467507 cites W2152323731 @default.
- W2019467507 cites W2152414109 @default.
- W2019467507 doi "https://doi.org/10.1002/eji.200635950" @default.
- W2019467507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16506288" @default.
- W2019467507 hasPublicationYear "2006" @default.
- W2019467507 type Work @default.
- W2019467507 sameAs 2019467507 @default.
- W2019467507 citedByCount "8" @default.
- W2019467507 countsByYear W20194675072013 @default.
- W2019467507 crossrefType "journal-article" @default.
- W2019467507 hasAuthorship W2019467507A5003632224 @default.
- W2019467507 hasBestOaLocation W20194675071 @default.
- W2019467507 hasConcept C101544691 @default.
- W2019467507 hasConcept C161879069 @default.
- W2019467507 hasConcept C201750760 @default.
- W2019467507 hasConcept C203014093 @default.
- W2019467507 hasConcept C2776090121 @default.
- W2019467507 hasConcept C2778690821 @default.
- W2019467507 hasConcept C2779282312 @default.
- W2019467507 hasConcept C28328180 @default.
- W2019467507 hasConcept C502942594 @default.
- W2019467507 hasConcept C62478195 @default.
- W2019467507 hasConcept C86803240 @default.
- W2019467507 hasConcept C8891405 @default.
- W2019467507 hasConcept C95444343 @default.
- W2019467507 hasConceptScore W2019467507C101544691 @default.
- W2019467507 hasConceptScore W2019467507C161879069 @default.
- W2019467507 hasConceptScore W2019467507C201750760 @default.
- W2019467507 hasConceptScore W2019467507C203014093 @default.
- W2019467507 hasConceptScore W2019467507C2776090121 @default.
- W2019467507 hasConceptScore W2019467507C2778690821 @default.
- W2019467507 hasConceptScore W2019467507C2779282312 @default.
- W2019467507 hasConceptScore W2019467507C28328180 @default.
- W2019467507 hasConceptScore W2019467507C502942594 @default.
- W2019467507 hasConceptScore W2019467507C62478195 @default.
- W2019467507 hasConceptScore W2019467507C86803240 @default.
- W2019467507 hasConceptScore W2019467507C8891405 @default.
- W2019467507 hasConceptScore W2019467507C95444343 @default.
- W2019467507 hasIssue "3" @default.
- W2019467507 hasLocation W20194675071 @default.
- W2019467507 hasLocation W20194675072 @default.
- W2019467507 hasOpenAccess W2019467507 @default.
- W2019467507 hasPrimaryLocation W20194675071 @default.
- W2019467507 hasRelatedWork W1980073120 @default.
- W2019467507 hasRelatedWork W2049845594 @default.
- W2019467507 hasRelatedWork W2111214065 @default.
- W2019467507 hasRelatedWork W2121878535 @default.
- W2019467507 hasRelatedWork W2135793203 @default.
- W2019467507 hasRelatedWork W2300366807 @default.
- W2019467507 hasRelatedWork W2379182815 @default.
- W2019467507 hasRelatedWork W2531798000 @default.
- W2019467507 hasRelatedWork W2801524442 @default.
- W2019467507 hasRelatedWork W3213450778 @default.
- W2019467507 hasVolume "36" @default.
- W2019467507 isParatext "false" @default.
- W2019467507 isRetracted "false" @default.
- W2019467507 magId "2019467507" @default.
- W2019467507 workType "article" @default.