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• W2019468145 abstract "Tungsten carbide (WC) and tungsten carbide cobalt (WC-Co) nanoparticles are of occupational health relevance because of the increasing usage in hard metal industries. Earlier studies showed an enhanced toxic potential for WC-Co compared to WC or cobalt ions alone. Therefore, we investigated the impact of these particles, compared to cobalt ions applied as CoCl(2), on the global gene expression level in human keratinocytes (HaCaT) in vitro.WC nanoparticles exerted very little effects on the transcriptomic level after 3 hours and 3 days of exposure. In contrast, WC-Co nanoparticles caused significant transcriptional changes that were similar to those provoked by CoCl(2). However, CoCl(2) exerted even more pronounced changes in the transcription patterns. Gene set enrichment analyses revealed that the differentially expressed genes were related to hypoxia response, carbohydrate metabolism, endocrine pathways, and targets of several transcription factors. The role of the transcription factor HIF1 (hypoxia inducible factor 1) is particularly highlighted and aspects of downstream events as well as the role of other transcription factors related to cobalt toxicity are considered.This study provides extensive data useful for the understanding of nanoparticle and cobalt toxicity. It shows that WC nanoparticles caused low transcriptional responses while WC-Co nanoparticles are able to exert responses similar to that of free cobalt ions, particularly the induction of hypoxia-like effects via interactions with HIF1alpha in human keratinocytes. However, the enhanced toxicity of WC-Co particles compared to CoCl(2) could not be explained by differences in gene transcription." @default.
• W2019468145 created "2016-06-24" @default.
• W2019468145 creator A5042487664 @default.
• W2019468145 creator A5052859681 @default.
• W2019468145 creator A5085551019 @default.
• W2019468145 creator A5091245009 @default.
• W2019468145 date "2010-01-01" @default.
• W2019468145 modified "2023-10-13" @default.
• W2019468145 title "Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes" @default.
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• W2019468145 cites W1548631381 @default.
• W2019468145 cites W1603041721 @default.
• W2019468145 cites W1968188089 @default.
• W2019468145 cites W1972002559 @default.
• W2019468145 cites W1973810183 @default.
• W2019468145 cites W1979854943 @default.
• W2019468145 cites W1980026775 @default.
• W2019468145 cites W1980182356 @default.
• W2019468145 cites W1981487137 @default.
• W2019468145 cites W1985982084 @default.
• W2019468145 cites W1996157249 @default.
• W2019468145 cites W1996903810 @default.
• W2019468145 cites W1999438528 @default.
• W2019468145 cites W2000976163 @default.
• W2019468145 cites W2001259429 @default.
• W2019468145 cites W2001367811 @default.
• W2019468145 cites W2004472644 @default.
• W2019468145 cites W2006499430 @default.
• W2019468145 cites W2009522838 @default.
• W2019468145 cites W2011678217 @default.
• W2019468145 cites W2021741218 @default.
• W2019468145 cites W2023092575 @default.
• W2019468145 cites W2023168515 @default.
• W2019468145 cites W2025291233 @default.
• W2019468145 cites W2034753110 @default.
• W2019468145 cites W2040228345 @default.
• W2019468145 cites W2041195114 @default.
• W2019468145 cites W2042216712 @default.
• W2019468145 cites W2045648071 @default.
• W2019468145 cites W2046440184 @default.
• W2019468145 cites W2051858548 @default.
• W2019468145 cites W2060254175 @default.
• W2019468145 cites W2064485592 @default.
• W2019468145 cites W2065221771 @default.
• W2019468145 cites W2068945609 @default.
• W2019468145 cites W2069527452 @default.
• W2019468145 cites W2070754110 @default.
• W2019468145 cites W2071020745 @default.
• W2019468145 cites W2072353704 @default.
• W2019468145 cites W2075828452 @default.
• W2019468145 cites W2076244798 @default.
• W2019468145 cites W2081771213 @default.
• W2019468145 cites W2082496903 @default.
• W2019468145 cites W2084746883 @default.
• W2019468145 cites W2086579338 @default.
• W2019468145 cites W2087468617 @default.
• W2019468145 cites W2090591741 @default.
• W2019468145 cites W2107854895 @default.
• W2019468145 cites W2117326659 @default.
• W2019468145 cites W2118547942 @default.
• W2019468145 cites W2120090919 @default.
• W2019468145 cites W2121425724 @default.
• W2019468145 cites W2122523158 @default.
• W2019468145 cites W2123106337 @default.
• W2019468145 cites W2123745142 @default.
• W2019468145 cites W2128381924 @default.
• W2019468145 cites W2130410032 @default.
• W2019468145 cites W2135414452 @default.
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• W2019468145 cites W2138845988 @default.
• W2019468145 cites W2141528928 @default.
• W2019468145 cites W2143464311 @default.
• W2019468145 cites W2144503403 @default.
• W2019468145 cites W2155118487 @default.
• W2019468145 cites W2155400170 @default.
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• W2019468145 cites W2157963288 @default.
• W2019468145 cites W2158217645 @default.
• W2019468145 cites W2160000741 @default.
• W2019468145 cites W2160821900 @default.
• W2019468145 cites W2161877652 @default.
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• W2019468145 doi "https://doi.org/10.1186/1471-2164-11-65" @default.
• W2019468145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2824725" @default.
• W2019468145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20105288" @default.
• W2019468145 hasPublicationYear "2010" @default.
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