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- W2019468959 endingPage "94" @default.
- W2019468959 startingPage "89" @default.
- W2019468959 abstract "In pregnancy, uterine spiral artery remodeling is an adaptive morphological change at the maternal and fetal interface, which is critical for dilating the artery and promoting blood flow to the fetus. Incompletely remodeled spiral arteries have been recognized as a common pathological feature in preeclamptic patients. To date, the molecular mechanism that controls spiral artery remodeling is not well defined. Corin is a transmembrane serine protease discovered in the heart, where it converts pro-atrial natriuretic peptide (pro-ANP) to active ANP, a cardiac hormone that regulates salt-water balance and blood pressure. Recent studies show that corin is up-regulated in the decidua of the pregnant uterus, suggesting a potential role of corin in pregnancy. In mice lacking corin or ANP, high blood pressure and proteinuria were found at late gestational stages. Histological analysis indicated delayed trophoblast invasion and impaired spiral artery remodeling in the uterus. In humans, CORIN gene mutations were identified in patients with preeclampsia. In this review, we discuss the function of corin and ANP in regulating blood pressure and their potential role in preeclampsia." @default.
- W2019468959 created "2016-06-24" @default.
- W2019468959 creator A5040456231 @default.
- W2019468959 creator A5061354837 @default.
- W2019468959 date "2013-02-01" @default.
- W2019468959 modified "2023-10-18" @default.
- W2019468959 title "Role of corin and atrial natriuretic peptide in preeclampsia" @default.
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