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- W2019475709 abstract "Abstract Platelets were found to take up tritium-labelled heparin either when platelet-rich plasma (PRP) was treated with the labelled heparin or if platelets, free of plasma proteins, obtained from chromatography of PRP on Sepharose 2B were treated with the tagged heparin. Sodium dodecyl sulfate (SDS) prevented uptake of heparin by platelets. Platelets were found to take up only “free” heparin but not heparin complexed with antithrombin III. 20% of the heparin was released by complete aggregation of the platelets. Treatment of 3 H-heparinized platelets with a low dose of sodium dodecyl sulfate which did not disrupt the platelets liberated 40%. The heparin released in both cases had anticoagulant activity. Treatment with the low dose SDS followed by aggregation and then higher doses of detergents freed almost all of the heparin. It is concluded that uptake of heparin by platelets may involve a combination of several constituents: 1) platelet factor 4, 2) surface membranes, and 3) other granules or cytoplasmic components. Inasmuch as platelets do not take up heparin combined with antithrombin III, the physiologic significance of the complexing of heparin by platelets has not been settled." @default.
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- W2019475709 title "The interaction of platelets with a tritium-labelled heparin" @default.
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- W2019475709 doi "https://doi.org/10.1016/0049-3848(76)90107-9" @default.
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