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- W2019475903 abstract "Abstract Administration of pharmacological doses of glucocorticoid suppressed the accumulation of liver proteins in young adult rats. In vivo pulse-labeling experiments showed that the protein synthesis activity of the liver was reduced by 70% on the sixth day of glucocorticoid treatment, and the electron microscopic examination of the glucocorticoid-treated liver cells revealed marked alterations in rough surfaced endoplasmic reticulum-polysome structures. The cell-free protein synthesis system containing the glucocorticoid-treated liver fractions incorporated only 37% as much radioactive precursor into proteins as did the system containing normal liver fractions. This result from the cell-free experiment also places the glucocorticoid induced lesions in the membrane-polysome fraction of the liver." @default.
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- W2019475903 title "Glucocorticoid induced lesions in rat livers" @default.
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- W2019475903 doi "https://doi.org/10.1016/0014-4800(75)90069-6" @default.
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