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- W2019480282 abstract "1.- The present study investigated the effects of a long-term treatment with clozapine on the clozapine-induced ACh overflow in the rat brain. 2.- Ten male Wistar rats received a daily ip clozapine injection (20 mg/Kg) for 21 days. Triple brain microdialysis was used to monitor the effects of the first and last injections (reinsertion group; n = 5) or just the last injection (single insertion group; n = 5) on the ACh outflow in the PFC, NAC, and STR. 3.- In the reinsertion group the ACh release changed neither in the PFC [310 ±77% after the first Vs 329 ± 54% after the last injection; (Fl/40: 0.3; NS) ] nor in the STR [144 ± 27% Vs 163 ± 12%; (F1/40: 1.1; NS) ] but was larger in the NAC after the chronic treatment [142 ± 20% Vs 211 ± 28%; [F1/40: 15.9; p<0.005). 4.- Rats that underwent the probe insertion only during the last day of treatment changed the ACh outflow after the same pattern of the reinsertion group, with the largest effect in the PFC (265 ± 26%) and a lower impact in the NAC (175 ± 25%) and STR (159 ± 18%). 5.- The lack of tolerance to the clozapine-induced ACh release in the PFC and the sensitization of this effect developed in the NAC suggest that activation of cholinergic systems within those areas could represent pharmacological actions responsible for some of the clozapine's therapeutical benefits." @default.
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- W2019480282 date "1998-11-01" @default.
- W2019480282 modified "2023-10-17" @default.
- W2019480282 title "Clozapine-induced acetylcholine release in the rat prefrontal cortex, nucleus accumbens and striatum does not develop tolerance" @default.
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- W2019480282 doi "https://doi.org/10.1016/s0278-5846(98)00076-1" @default.
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