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- W2019485227 abstract "Growing evidence suggests that some immune responses are mediated not only by conventional and distinct NK cells and CTL, but also by T cell subsets expressing NK receptors and NK cell-associated molecules. Consistent with our previously published finding that the mAb 1F8 identifies non-T/non-B cells in Xenopus that effect NK-like killing in vitro, we now report that in vivo treatment with this mAb impairs rejection of transplanted MHC class I-negative tumor cells. However, we also find that the NK cell-associated molecule recognized by mAb 1F8 is expressed by a minor population of CD8+ T cells, in which fully rearranged TCRβ mRNA of at least three different V families can be identified, by contrast, 1F8+/CD8– (NK) cells lack such TCRβ message. Additionally, the expression of the NK cell-associated molecule can be induced in vitro by a transient submitogenic stimulation of naïve CD8+ T cells with PMA and ionomycin. Such induced expression of 1F8 also occurs in alloantigen-activated CTL and is coincident with a down-regulation of MHC-specific cytotoxicity. Taken together, these new data suggest that regulation of CD8+ T cell activity involving NK cell-associated molecules is a general and evolutionarily ancient phenomenon." @default.
- W2019485227 created "2016-06-24" @default.
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- W2019485227 date "2002-06-01" @default.
- W2019485227 modified "2023-10-03" @default.
- W2019485227 title "Identification and characterization of Xenopus CD8+ T cells expressing an NK cell-associated molecule" @default.
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- W2019485227 doi "https://doi.org/10.1002/1521-4141(200206)32:6<1574::aid-immu1574>3.0.co;2-4" @default.
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