FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019485800> ?p ?o ?g. }

• W2019485800 endingPage "160" @default.
• W2019485800 startingPage "149" @default.
• W2019485800 abstract "The lung, in particular the bronchial epithelium, is a major site for tumor formation in humans. Environmental factors, such as cigarette smoke, in conjunction with genetic factors are important determinants in this disease. Malignant cells exhibit alterations in their control of proliferation and differentiation. It is believed that the acquisition of defects in the regulation of these processes is important in the process of carcinogenesis. A clear insight into the basic mechanisms of the regulation of proliferation and differentiation is required to understand the molecular mechanisms involved in tumor development and in other pathological conditions. Studies using in vitro cell culture systems of tracheobronchial epithelial cells provide useful models in which to study the regulation of differentiation and proliferation. The clonogenic cells derived from the treacheobronchial epithelium are pluripotent: They have self-renewal capacity and can differentiate along either a normal, mucosecretory, or a squamous cell pathway. Squamous differentiation in tracheobronchial epithelial cells has many morphological, biochemical, and regulatory properties in common with epidermal differentiation. This pathway of differentiation is a multistep process consisting of at least three stages. In the initial stage, cells become committed to terminal cell division. This is followed by the expression of the squamous differentiated phenotype and finally cornification. Various factors, such as several growth factors, retinoids, calcium ions, and phorbol esters, regulate the program of differentiation at different stages. Studies have indicated that the controls of proliferation and differentiation are interrelated. Cell lines established from tracheobronchial epithelial cells expressing SV 40 large T-antigen, as well as carcinoma cell lines, exhibit altered responses to growth and differentiation regulatory factors. Alterations in the commitment to terminal cell division must be a crucial step in the transition of a normal to a malignant cell." @default.
• W2019485800 created "2016-06-24" @default.
• W2019485800 creator A5007501845 @default.
• W2019485800 date "1989-03-01" @default.
• W2019485800 modified "2023-09-30" @default.
• W2019485800 title "Multistep process of squamous differentiation in tracheobronchial epithelial cells in vitro: analogy with epidermal differentiation." @default.
• W2019485800 cites W133445481 @default.
• W2019485800 cites W1505229765 @default.
• W2019485800 cites W1509073604 @default.
• W2019485800 cites W1509951428 @default.
• W2019485800 cites W1513452394 @default.
• W2019485800 cites W1519913430 @default.
• W2019485800 cites W1525615122 @default.
• W2019485800 cites W1538990103 @default.
• W2019485800 cites W1539901397 @default.
• W2019485800 cites W1554438070 @default.
• W2019485800 cites W1572766341 @default.
• W2019485800 cites W1604168217 @default.
• W2019485800 cites W1604444075 @default.
• W2019485800 cites W1612390895 @default.
• W2019485800 cites W1662582947 @default.
• W2019485800 cites W1757031429 @default.
• W2019485800 cites W1816119612 @default.
• W2019485800 cites W1885416547 @default.
• W2019485800 cites W1913952795 @default.
• W2019485800 cites W1967749441 @default.
• W2019485800 cites W1968997237 @default.
• W2019485800 cites W1973644988 @default.
• W2019485800 cites W1973668507 @default.
• W2019485800 cites W1973869185 @default.
• W2019485800 cites W1974469880 @default.
• W2019485800 cites W1976479967 @default.
• W2019485800 cites W1976992030 @default.
• W2019485800 cites W1977451386 @default.
• W2019485800 cites W1978245541 @default.
• W2019485800 cites W1979580749 @default.
• W2019485800 cites W1981880855 @default.
• W2019485800 cites W1983851236 @default.
• W2019485800 cites W1987297184 @default.
• W2019485800 cites W1987726188 @default.
• W2019485800 cites W1988396591 @default.
• W2019485800 cites W1989468162 @default.
• W2019485800 cites W1989588484 @default.
• W2019485800 cites W1990545618 @default.
• W2019485800 cites W1992172901 @default.
• W2019485800 cites W1993815025 @default.
• W2019485800 cites W2000569630 @default.
• W2019485800 cites W2001668713 @default.
• W2019485800 cites W2001692359 @default.
• W2019485800 cites W2001716659 @default.
• W2019485800 cites W2002713013 @default.
• W2019485800 cites W2002946136 @default.
• W2019485800 cites W2005356516 @default.
• W2019485800 cites W2007768242 @default.
• W2019485800 cites W2008139927 @default.
• W2019485800 cites W2012960732 @default.
• W2019485800 cites W2014798096 @default.
• W2019485800 cites W2015095403 @default.
• W2019485800 cites W2018117114 @default.
• W2019485800 cites W2018650295 @default.
• W2019485800 cites W2019441796 @default.
• W2019485800 cites W2020088099 @default.
• W2019485800 cites W2020774254 @default.
• W2019485800 cites W2021532564 @default.
• W2019485800 cites W2022608661 @default.
• W2019485800 cites W2032390881 @default.
• W2019485800 cites W2038085058 @default.
• W2019485800 cites W2038438177 @default.
• W2019485800 cites W2038905259 @default.
• W2019485800 cites W2041150657 @default.
• W2019485800 cites W2045680499 @default.
• W2019485800 cites W2045959356 @default.
• W2019485800 cites W2046980821 @default.
• W2019485800 cites W2049791242 @default.
• W2019485800 cites W2050038418 @default.
• W2019485800 cites W2051214356 @default.
• W2019485800 cites W2051665279 @default.
• W2019485800 cites W2057044666 @default.
• W2019485800 cites W2059234792 @default.
• W2019485800 cites W2060950632 @default.
• W2019485800 cites W2061237145 @default.
• W2019485800 cites W2062300120 @default.
• W2019485800 cites W2062660778 @default.
• W2019485800 cites W2063482010 @default.
• W2019485800 cites W2067701204 @default.
• W2019485800 cites W2069683833 @default.
• W2019485800 cites W2069810321 @default.
• W2019485800 cites W2070909725 @default.
• W2019485800 cites W2072233737 @default.
• W2019485800 cites W2074915714 @default.
• W2019485800 cites W2075228263 @default.
• W2019485800 cites W2077814789 @default.
• W2019485800 cites W2077996184 @default.
• W2019485800 cites W2082076255 @default.
• W2019485800 cites W2083012075 @default.
• W2019485800 cites W2084799148 @default.
• W2019485800 cites W2085137882 @default.
• W2019485800 cites W2086024644 @default.

• next