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• W2019486394 abstract "Abstract The role of estrogen in the regulation ofnuterine aldolase (fructose-1,6-diphosphate D -glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13) has been investigated in ovariectomized rats. 1. 1. A progressive decline in uterine aldolase activity, whether expressed per total uterus or per mg DNA, was noted during the first 14 days of castration. 2. 2. Administration of estradiol to ovariectomized rats reversed these effects of ovariectomy. Time-course studies demonstrated that a single intramuscular injection of estradiol-17β (10.0 μg/100 g) produced a significant increase in uterine aldolase at 4 h which reached peak levels at 16 h. Dose-response studies revealed that amounts of estradiol as low as 0.1 gmg/100 g were capable of producing significant increases in uterine enzyme activity. 3. 3. The hormone-induced increases in uterine aldolase were inhibited completely by the administration of ethamoxytriphetol to estradiol-treated rats although this anti-estrogen by itself produced a slight increase (125%) in aldolase activity. 4. 4. Evidence for the involvement of new RNA and protein synthesis in the observed estradiol stimulation of uterine aldolase was obtained with the use of actinomycin D and cycloheximide. These inhibitors, when administered simultaneously with the hormone, prevented the estrogen-induced increases in the activity of uterine aldolase. However, when the administration of actinomycin was delayed for 2, 6 and 12 h after estradiol injection, the ability of this antibiotic to prevent the observed enzyme increases progressively decreased, indicating that the early stimulation of RNA synthesis is involved in the observed induction of the uterine enzyme. 5. 5. The data suggest that estrogenic hormones exert a regulatory influence on uterine aldolase and that the enhanced uterine glycolysis observed after estradiol administration may be related to an increased synthesis of aldolase along with other glycolytic enzymes." @default.
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• W2019486394 title "Metabolic control mechanisms in mammalian systems VII. Estrogenic induction of fructose-1,6-diphosphate aldolase in the rat uterus" @default.
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• W2019486394 doi "https://doi.org/10.1016/0304-4165(69)90015-4" @default.
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