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- W2019486402 abstract "Abstract The cyclic model for drug-receptor interaction predicts a hyperbolic relationship between response and concentration provided that the drug equilibrates instantaneously with the receptors. It is shown theoretically that if equilibration is not very much faster than desensitization and recovery, the response-concentration relationship appears to exhibit negative co-operativity. On the other hand, if the drug also diffuses relatively slowly to the receptors the relationship may appear to exhibit positive co-operativity." @default.
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- W2019486402 modified "2023-09-27" @default.
- W2019486402 title "Co-operativity in the cyclic model for drug-receptor interaction" @default.
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- W2019486402 doi "https://doi.org/10.1016/0006-2952(76)90197-0" @default.
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