Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019489580> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2019489580 endingPage "1461" @default.
- W2019489580 startingPage "1454" @default.
- W2019489580 abstract "Carzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I study, Carzelesin was given as a 4-weekly 10 min IV infusion to 51 patients with advanced solid tumours. Patients received a median of two courses (range 1–5) at one of nine dose levels: 24, 48, 96, 130, 150, 170, 210, 250 and 300 μg m–2. According to NCI-CTC criteria, non-haematological toxicities (grade 1/2) included fever, nausea and vomiting, mucositis and anorexia, none of which was clearly dose related. The dose-limiting toxicity was haematological and consisted mainly of neutropenia and to a lesser extent thrombocytopenia. From the dose level 150 μg m–2, the haematological toxicity (particularly thrombocytopenia) was delayed in onset, prolonged and cumulative in some patients. In several courses, double WBC nadirs occurred. The maximum tolerated dose for a single course was 300 μg m–2. From the dose level 170 μg m–2, the intended dose intensity could not be delivered to most patients receiving > 2 courses owing to cumulative haematological toxicity. The dose level with the best dose intensity for multiple courses was 150 μg m–2. The pharmacokinetics of Carzelesin and its metabolites (U-76,073; U-76,074) have been established in 31 patients during the first course of treatment using a HPLC method. Carzelesin exhibited linear pharmacokinetics. The concentration of U-76,074 (active metabolite) extended above the lower limit of quantitation (1 ng ml–1) for short periods of time and only at the higher dose levels. There was no relationship between neutropenia and the AUC of the prodrug Carzelesin, but the presence of detectable plasma levels of the active metabolite U-76,074 was usually associated with a substantial decrease in ANC values." @default.
- W2019489580 created "2016-06-24" @default.
- W2019489580 creator A5002860762 @default.
- W2019489580 creator A5010064853 @default.
- W2019489580 creator A5011819733 @default.
- W2019489580 creator A5015603649 @default.
- W2019489580 creator A5034151807 @default.
- W2019489580 creator A5035148753 @default.
- W2019489580 creator A5058788968 @default.
- W2019489580 creator A5063712485 @default.
- W2019489580 creator A5086833629 @default.
- W2019489580 creator A5087380706 @default.
- W2019489580 date "1999-02-26" @default.
- W2019489580 modified "2023-10-07" @default.
- W2019489580 title "Phase I study of Carzelesin (U-80,244) given (4-weekly) by intravenous bolus schedule" @default.
- W2019489580 cites W1563595970 @default.
- W2019489580 cites W1566156137 @default.
- W2019489580 cites W1619297620 @default.
- W2019489580 cites W1823270173 @default.
- W2019489580 cites W1965480599 @default.
- W2019489580 cites W1972780065 @default.
- W2019489580 cites W2000738723 @default.
- W2019489580 cites W2009471244 @default.
- W2019489580 cites W2061481557 @default.
- W2019489580 cites W2078565719 @default.
- W2019489580 cites W2079580408 @default.
- W2019489580 cites W2080127138 @default.
- W2019489580 cites W2094089146 @default.
- W2019489580 cites W2322028449 @default.
- W2019489580 cites W2435940122 @default.
- W2019489580 doi "https://doi.org/10.1038/sj.bjc.6690232" @default.
- W2019489580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2362731" @default.
- W2019489580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10188890" @default.
- W2019489580 hasPublicationYear "1999" @default.
- W2019489580 type Work @default.
- W2019489580 sameAs 2019489580 @default.
- W2019489580 citedByCount "12" @default.
- W2019489580 countsByYear W20194895802017 @default.
- W2019489580 countsByYear W20194895802019 @default.
- W2019489580 countsByYear W20194895802023 @default.
- W2019489580 crossrefType "journal-article" @default.
- W2019489580 hasAuthorship W2019489580A5002860762 @default.
- W2019489580 hasAuthorship W2019489580A5010064853 @default.
- W2019489580 hasAuthorship W2019489580A5011819733 @default.
- W2019489580 hasAuthorship W2019489580A5015603649 @default.
- W2019489580 hasAuthorship W2019489580A5034151807 @default.
- W2019489580 hasAuthorship W2019489580A5035148753 @default.
- W2019489580 hasAuthorship W2019489580A5058788968 @default.
- W2019489580 hasAuthorship W2019489580A5063712485 @default.
- W2019489580 hasAuthorship W2019489580A5086833629 @default.
- W2019489580 hasAuthorship W2019489580A5087380706 @default.
- W2019489580 hasBestOaLocation W20194895801 @default.
- W2019489580 hasConcept C112705442 @default.
- W2019489580 hasConcept C126322002 @default.
- W2019489580 hasConcept C151032500 @default.
- W2019489580 hasConcept C2777063308 @default.
- W2019489580 hasConcept C2778496288 @default.
- W2019489580 hasConcept C2780580376 @default.
- W2019489580 hasConcept C2780852908 @default.
- W2019489580 hasConcept C29730261 @default.
- W2019489580 hasConcept C43376680 @default.
- W2019489580 hasConcept C71924100 @default.
- W2019489580 hasConcept C90924648 @default.
- W2019489580 hasConcept C98274493 @default.
- W2019489580 hasConceptScore W2019489580C112705442 @default.
- W2019489580 hasConceptScore W2019489580C126322002 @default.
- W2019489580 hasConceptScore W2019489580C151032500 @default.
- W2019489580 hasConceptScore W2019489580C2777063308 @default.
- W2019489580 hasConceptScore W2019489580C2778496288 @default.
- W2019489580 hasConceptScore W2019489580C2780580376 @default.
- W2019489580 hasConceptScore W2019489580C2780852908 @default.
- W2019489580 hasConceptScore W2019489580C29730261 @default.
- W2019489580 hasConceptScore W2019489580C43376680 @default.
- W2019489580 hasConceptScore W2019489580C71924100 @default.
- W2019489580 hasConceptScore W2019489580C90924648 @default.
- W2019489580 hasConceptScore W2019489580C98274493 @default.
- W2019489580 hasIssue "9-10" @default.
- W2019489580 hasLocation W20194895801 @default.
- W2019489580 hasLocation W20194895802 @default.
- W2019489580 hasLocation W20194895803 @default.
- W2019489580 hasLocation W20194895804 @default.
- W2019489580 hasOpenAccess W2019489580 @default.
- W2019489580 hasPrimaryLocation W20194895801 @default.
- W2019489580 hasRelatedWork W1980701009 @default.
- W2019489580 hasRelatedWork W2074629895 @default.
- W2019489580 hasRelatedWork W2243375749 @default.
- W2019489580 hasRelatedWork W2347542215 @default.
- W2019489580 hasRelatedWork W2369096216 @default.
- W2019489580 hasRelatedWork W2370377759 @default.
- W2019489580 hasRelatedWork W2374367026 @default.
- W2019489580 hasRelatedWork W2375012438 @default.
- W2019489580 hasRelatedWork W2389233550 @default.
- W2019489580 hasRelatedWork W4300573830 @default.
- W2019489580 hasVolume "79" @default.
- W2019489580 isParatext "false" @default.
- W2019489580 isRetracted "false" @default.
- W2019489580 magId "2019489580" @default.
- W2019489580 workType "article" @default.