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• W2019494037 abstract "N-BAR domains are protein modules that bind to and induce curvature in membranes via a charged concave surface and N-terminal amphipathic helices. Recently, molecular dynamics simulations have demonstrated that the N-BAR domain can induce a strong local curvature that matches the curvature of the BAR domain surface facing the bilayer. Here we present further molecular dynamics simulations that examine in greater detail the roles of the concave surface and amphipathic helices in driving local membrane curvature. We find that the strong curvature induction observed in our previous simulations requires the stable presentation of the charged concave surface to the membrane and is not driven by the membrane-embedded amphipathic helices. Nevertheless, without these amphipathic helices embedded in the membrane, the N-BAR domain does not maintain a close association with the bilayer, and fails to drive membrane curvature. Increasing the membrane negative charge through the addition of PIP(2) facilitates closer association with the membrane in the absence of embedded helices. At sufficiently high concentrations, amphipathic helices embedded in the membrane drive membrane curvature independently of the BAR domain." @default.
• W2019494037 created "2016-06-24" @default.
• W2019494037 creator A5033548783 @default.
• W2019494037 creator A5037662959 @default.
• W2019494037 creator A5088327041 @default.
• W2019494037 date "2008-08-01" @default.
• W2019494037 modified "2023-10-12" @default.
• W2019494037 title "Factors Influencing Local Membrane Curvature Induction by N-BAR Domains as Revealed by Molecular Dynamics Simulations" @default.
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• W2019494037 doi "https://doi.org/10.1529/biophysj.107.121160" @default.
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