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- W2019495983 abstract "Phosphoinositides function as important second messengers in a wide range of cellular processes. Inositol polyphosphate 1-phosphatase (IPP) is an enzyme essential for the hydrolysis of the 1-phosphate from either Ins(1,4)P2 or Ins(1,3,4)P3. This enzyme is Li+ sensitive, and is one of the proposed targets of Li+ therapy in manic-depressive illness. Drosophila ipp mutants accumulate IP2 in their system and are incapable of metabolizing exogenous Ins(1,4)P2. Notably, ipp mutants demonstrate compensatory upregulation of an alternative branch in the inositol-phosphate metabolism tree, thus providing a means of ensuring continued availability of inositol. We demonstrate that ipp mutants have a defect in synaptic transmission resulting from a dramatic increase in the probability of vesicle release at larval neuromuscular junctions. We also show that Li+ phenocopies this effect in wild-type synapses. Together, these results support a role for phosphoinositides in synaptic vesicle function in vivo and mechanistically question the lithium hypothesis." @default.
- W2019495983 created "2016-06-24" @default.
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- W2019495983 date "1998-06-01" @default.
- W2019495983 modified "2023-10-02" @default.
- W2019495983 title "Synaptic Defects and Compensatory Regulation of Inositol Metabolism in Inositol Polyphosphate 1-Phosphatase Mutants" @default.
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- W2019495983 doi "https://doi.org/10.1016/s0896-6273(00)80502-4" @default.
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