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- W2019508559 abstract "Productive infection of human T lymphocytes by HIV-1 is dependent upon proliferation of the infected cell. Nonproliferating quiescent T cells can be infected by HIV-1 and harbor the virus in an inactive state until subsequent mitogenic stimulation. We use a modification of the polymerase chain reaction method, which is both sensitive and quantitative, to demonstrate that HIV-1 DNA synthesis is initiated in infected quiescent T cells at levels comparable with those of activated T cells. However, unlike that of activated T cells, the viral genome is not completely reverse transcribed in quiescent cells. Although this viral DNA structure can persist in quiescent cells as a latent form, it is labile. We discuss the lability of this HIV-1 DNA structure in relation to a self-restricting persistent infection by HIV-1 and propose that this may explain the low percentage of infected cells in the circulation of AIDS patients." @default.
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- W2019508559 date "1990-04-01" @default.
- W2019508559 modified "2023-10-12" @default.
- W2019508559 title "HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure" @default.
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- W2019508559 doi "https://doi.org/10.1016/0092-8674(90)90802-l" @default.
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