FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019515024> ?p ?o ?g. }

• W2019515024 endingPage "e1002457" @default.
• W2019515024 startingPage "e1002457" @default.
• W2019515024 abstract "Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great importance to unravel the molecular mechanisms by which an adverse drug reaction can be potentially elicited. These mechanisms can be investigated by placing the pharmaco-epidemiologically detected adverse drug reaction in an information-rich context and by exploiting all currently available biomedical knowledge to substantiate it. We present a computational framework for the biological annotation of potential adverse drug reactions. First, the proposed framework investigates previous evidences on the drug-event association in the context of biomedical literature (signal filtering). Then, it seeks to provide a biological explanation (signal substantiation) by exploring mechanistic connections that might explain why a drug produces a specific adverse reaction. The mechanistic connections include the activity of the drug, related compounds and drug metabolites on protein targets, the association of protein targets to clinical events, and the annotation of proteins (both protein targets and proteins associated with clinical events) to biological pathways. Hence, the workflows for signal filtering and substantiation integrate modules for literature and database mining, in silico drug-target profiling, and analyses based on gene-disease networks and biological pathways. Application examples of these workflows carried out on selected cases of drug safety signals are discussed. The methodology and workflows presented offer a novel approach to explore the molecular mechanisms underlying adverse drug reactions." @default.
• W2019515024 created "2016-06-24" @default.
• W2019515024 creator A5005077862 @default.
• W2019515024 creator A5013575923 @default.
• W2019515024 creator A5021121744 @default.
• W2019515024 creator A5022745319 @default.
• W2019515024 creator A5025304492 @default.
• W2019515024 creator A5028427590 @default.
• W2019515024 creator A5030710827 @default.
• W2019515024 creator A5030997667 @default.
• W2019515024 creator A5034080499 @default.
• W2019515024 creator A5039453222 @default.
• W2019515024 creator A5040524956 @default.
• W2019515024 creator A5052116809 @default.
• W2019515024 creator A5054199754 @default.
• W2019515024 creator A5056335906 @default.
• W2019515024 creator A5077097006 @default.
• W2019515024 creator A5081807521 @default.
• W2019515024 date "2012-04-05" @default.
• W2019515024 modified "2023-10-11" @default.
• W2019515024 title "Automatic Filtering and Substantiation of Drug Safety Signals" @default.
• W2019515024 cites W1560686237 @default.
• W2019515024 cites W1966495638 @default.
• W2019515024 cites W1969879564 @default.
• W2019515024 cites W1979845492 @default.
• W2019515024 cites W1981024070 @default.
• W2019515024 cites W1985755631 @default.
• W2019515024 cites W1987908892 @default.
• W2019515024 cites W1989986729 @default.
• W2019515024 cites W1990676371 @default.
• W2019515024 cites W2008574207 @default.
• W2019515024 cites W2008939152 @default.
• W2019515024 cites W2009313526 @default.
• W2019515024 cites W2011726136 @default.
• W2019515024 cites W2016935074 @default.
• W2019515024 cites W2018588587 @default.
• W2019515024 cites W2024908724 @default.
• W2019515024 cites W2041097104 @default.
• W2019515024 cites W2041506510 @default.
• W2019515024 cites W2046885214 @default.
• W2019515024 cites W2054118966 @default.
• W2019515024 cites W2056001419 @default.
• W2019515024 cites W2056519407 @default.
• W2019515024 cites W2069310511 @default.
• W2019515024 cites W2106876831 @default.
• W2019515024 cites W2110717975 @default.
• W2019515024 cites W2115570304 @default.
• W2019515024 cites W2121365028 @default.
• W2019515024 cites W2126502758 @default.
• W2019515024 cites W2126703991 @default.
• W2019515024 cites W2128647433 @default.
• W2019515024 cites W2131152203 @default.
• W2019515024 cites W2132490382 @default.
• W2019515024 cites W2132992030 @default.
• W2019515024 cites W2137999759 @default.
• W2019515024 cites W2142302575 @default.
• W2019515024 cites W2145123170 @default.
• W2019515024 cites W2147418473 @default.
• W2019515024 cites W2148303708 @default.
• W2019515024 cites W2154896031 @default.
• W2019515024 cites W2159583324 @default.
• W2019515024 cites W2159675211 @default.
• W2019515024 cites W2164327527 @default.
• W2019515024 cites W2168103533 @default.
• W2019515024 cites W2169049983 @default.
• W2019515024 cites W2171956687 @default.
• W2019515024 cites W4243104410 @default.
• W2019515024 cites W4256005482 @default.
• W2019515024 doi "https://doi.org/10.1371/journal.pcbi.1002457" @default.
• W2019515024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3320573" @default.
• W2019515024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22496632" @default.
• W2019515024 hasPublicationYear "2012" @default.
• W2019515024 type Work @default.
• W2019515024 sameAs 2019515024 @default.
• W2019515024 citedByCount "32" @default.
• W2019515024 countsByYear W20195150242012 @default.
• W2019515024 countsByYear W20195150242013 @default.
• W2019515024 countsByYear W20195150242014 @default.
• W2019515024 countsByYear W20195150242015 @default.
• W2019515024 countsByYear W20195150242016 @default.
• W2019515024 countsByYear W20195150242017 @default.
• W2019515024 countsByYear W20195150242018 @default.
• W2019515024 countsByYear W20195150242019 @default.
• W2019515024 crossrefType "journal-article" @default.
• W2019515024 hasAuthorship W2019515024A5005077862 @default.
• W2019515024 hasAuthorship W2019515024A5013575923 @default.
• W2019515024 hasAuthorship W2019515024A5021121744 @default.
• W2019515024 hasAuthorship W2019515024A5022745319 @default.
• W2019515024 hasAuthorship W2019515024A5025304492 @default.
• W2019515024 hasAuthorship W2019515024A5028427590 @default.
• W2019515024 hasAuthorship W2019515024A5030710827 @default.
• W2019515024 hasAuthorship W2019515024A5030997667 @default.
• W2019515024 hasAuthorship W2019515024A5034080499 @default.
• W2019515024 hasAuthorship W2019515024A5039453222 @default.
• W2019515024 hasAuthorship W2019515024A5040524956 @default.
• W2019515024 hasAuthorship W2019515024A5052116809 @default.
• W2019515024 hasAuthorship W2019515024A5054199754 @default.
• W2019515024 hasAuthorship W2019515024A5056335906 @default.

• next