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• W201954255 startingPage "185" @default.
• W201954255 abstract "ConclusionThe growing HIV epidemic in Africa increases the need for immunologic assays that will provide data that can guide clinical decisions about disease management. Use of ARV drugs for the treatment of HIV and AIDS is currently beyond the economic reach of most Africans infected with HIV. However, there is growing interest among donor organizations and international agencies to initiate programs that would reduce or subsidize the cost of ARV drugs to individuals in African countries. In such programs, immune status monitoring will be required to provide the information for decisions on when to initiate ARV treatment, how to evaluate the clinical response of patients, and how to assess the effect of such therapy on disease progression. Methods for the quantification of CD4 + T-lymphocyte counts will therefore be needed as a complement or alternative to viral load measurement, depending upon available resources. Determining the levels of immune activation markers may also be of value. However, the use of surrogate markers for immune status monitoring in Africa will have to address some challenges, including a paucity of baseline reference values for most of the markers, and the role of genetic factors, other tropical diseases, and environment in immune activation.In view of the need for a safe, effective vaccine for HIV that will complement other prevention strategies, efficacy trials of candidate vaccines will require the participation of countries in Africa where the incidence of HIV is high. Monitoring immune system responses in vaccine trials will demand measuring HIV-specific CD4 + and CD8 + Tlymphocyte activity as well as viral neutralization activity." @default.
• W201954255 created "2016-06-24" @default.
• W201954255 creator A5057965152 @default.
• W201954255 creator A5061857469 @default.
• W201954255 date "2005-12-23" @default.
• W201954255 modified "2023-10-14" @default.
• W201954255 title "Monitoring Immune Function" @default.
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