Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019555832> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2019555832 endingPage "38" @default.
- W2019555832 startingPage "29" @default.
- W2019555832 abstract "The malignant diagnosis of a haematological disorder can in most cases be made by clinical signs and routine microscopic examination. However, it has become necessary to characterize the malignant clone with various markers, which give either knowledge of the prognosis of the disease or give tools for the laboratory follow up of the patient.In lymphatic diseases there are excellent markers of clonality. On the contrary in myeloid malignancies the few well characterized markers are mostly helpful in the clinical management of rare myeloid subgroups. The aim of our project has been to develop methods for laboratory monitoring of myeloid diseases by two major approaches 1) detection of methylation alterations in the short arm of chromosome 11 and 2) novel approaches for sensitive point mutation detection.The short arm of chromosome 11 has areas where the DNA becomes hyper-methylated in acute leukemias and lymphomas. In this chromosomal area the calcitonin gene serves as a good marker for methylation alterations due to several CpG sites in the 5′area of the gene. Even if the gene is normally methylated in most cases of chronic myeloid leukemia (CML), we have found that the hypermethylation of the calcitonin gene marks progression of CML and precedes any other signs of acceleration with several months.The point mutations of certain proto-oncogenes, such as the N-ras gene, are attractive markers for detecting residual diseases after chemotherapy of high malignant haematological disorders. However, conventional methods for detecting point mutations have been both insensitive and cumbersome, and thus unsuitable for clinical routine laboratories. With the solid-phase minisequencing we can technically easily and accurately detect small quantities of mutated cells." @default.
- W2019555832 created "2016-06-24" @default.
- W2019555832 creator A5066249724 @default.
- W2019555832 creator A5083066362 @default.
- W2019555832 date "1993-01-01" @default.
- W2019555832 modified "2023-10-16" @default.
- W2019555832 title "Development of molecular genetic methods for monitoring myeloid malignancies" @default.
- W2019555832 cites W115186932 @default.
- W2019555832 cites W1510833310 @default.
- W2019555832 cites W1583035638 @default.
- W2019555832 cites W1585617332 @default.
- W2019555832 cites W1749054014 @default.
- W2019555832 cites W1787537093 @default.
- W2019555832 cites W1821860584 @default.
- W2019555832 cites W193532439 @default.
- W2019555832 cites W1955257539 @default.
- W2019555832 cites W1974839297 @default.
- W2019555832 cites W1986167448 @default.
- W2019555832 cites W1988051356 @default.
- W2019555832 cites W2035049668 @default.
- W2019555832 cites W2042443618 @default.
- W2019555832 cites W2045322395 @default.
- W2019555832 cites W205209830 @default.
- W2019555832 cites W2087079130 @default.
- W2019555832 cites W2090205848 @default.
- W2019555832 cites W2104557589 @default.
- W2019555832 cites W2342164073 @default.
- W2019555832 cites W2396892382 @default.
- W2019555832 cites W2464303658 @default.
- W2019555832 cites W4242822964 @default.
- W2019555832 doi "https://doi.org/10.3109/00365519309090671" @default.
- W2019555832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8322016" @default.
- W2019555832 hasPublicationYear "1993" @default.
- W2019555832 type Work @default.
- W2019555832 sameAs 2019555832 @default.
- W2019555832 citedByCount "7" @default.
- W2019555832 crossrefType "journal-article" @default.
- W2019555832 hasAuthorship W2019555832A5066249724 @default.
- W2019555832 hasAuthorship W2019555832A5083066362 @default.
- W2019555832 hasConcept C104317684 @default.
- W2019555832 hasConcept C142724271 @default.
- W2019555832 hasConcept C150194340 @default.
- W2019555832 hasConcept C176944494 @default.
- W2019555832 hasConcept C190727270 @default.
- W2019555832 hasConcept C2778729363 @default.
- W2019555832 hasConcept C2779282312 @default.
- W2019555832 hasConcept C2779823535 @default.
- W2019555832 hasConcept C2780007613 @default.
- W2019555832 hasConcept C2994225774 @default.
- W2019555832 hasConcept C501734568 @default.
- W2019555832 hasConcept C502942594 @default.
- W2019555832 hasConcept C54355233 @default.
- W2019555832 hasConcept C71924100 @default.
- W2019555832 hasConcept C86803240 @default.
- W2019555832 hasConceptScore W2019555832C104317684 @default.
- W2019555832 hasConceptScore W2019555832C142724271 @default.
- W2019555832 hasConceptScore W2019555832C150194340 @default.
- W2019555832 hasConceptScore W2019555832C176944494 @default.
- W2019555832 hasConceptScore W2019555832C190727270 @default.
- W2019555832 hasConceptScore W2019555832C2778729363 @default.
- W2019555832 hasConceptScore W2019555832C2779282312 @default.
- W2019555832 hasConceptScore W2019555832C2779823535 @default.
- W2019555832 hasConceptScore W2019555832C2780007613 @default.
- W2019555832 hasConceptScore W2019555832C2994225774 @default.
- W2019555832 hasConceptScore W2019555832C501734568 @default.
- W2019555832 hasConceptScore W2019555832C502942594 @default.
- W2019555832 hasConceptScore W2019555832C54355233 @default.
- W2019555832 hasConceptScore W2019555832C71924100 @default.
- W2019555832 hasConceptScore W2019555832C86803240 @default.
- W2019555832 hasIssue "sup213" @default.
- W2019555832 hasLocation W20195558321 @default.
- W2019555832 hasLocation W20195558322 @default.
- W2019555832 hasOpenAccess W2019555832 @default.
- W2019555832 hasPrimaryLocation W20195558321 @default.
- W2019555832 hasRelatedWork W1996908110 @default.
- W2019555832 hasRelatedWork W2025824297 @default.
- W2019555832 hasRelatedWork W2151295331 @default.
- W2019555832 hasRelatedWork W2360105106 @default.
- W2019555832 hasRelatedWork W2371225407 @default.
- W2019555832 hasRelatedWork W2383384759 @default.
- W2019555832 hasRelatedWork W2410107327 @default.
- W2019555832 hasRelatedWork W3084449455 @default.
- W2019555832 hasRelatedWork W3199935574 @default.
- W2019555832 hasRelatedWork W293435227 @default.
- W2019555832 hasVolume "53" @default.
- W2019555832 isParatext "false" @default.
- W2019555832 isRetracted "false" @default.
- W2019555832 magId "2019555832" @default.
- W2019555832 workType "article" @default.