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- W2019561816 abstract "In vertebrates, a limited number of homeobox-containing transcription factors are expressed in the optic vesicle primordium and are required and sufficient for eye formation. At present, little is known about the distinct functions of these factors in optic vesicle growth and on the nature of the main neuroepithelial (NE) progenitor population present in this organ. We have characterized a multipotent cell population present in the mouse optic vesicle that shows extensive proliferation potential and which expresses NE progenitor and retinal markers in vitro. In Pax6 mutant embryos, which form an optic vesicle, we found that the number of resident NE progenitors was greater than normal. In vitro, Pax6-null NE progenitors overproliferate and display reduced p16Ink4a, p19Arf, p27kip1, p57kip2, and p21cip1 expression. Pax6 overexpression repressed cellular proliferation and secondary colonies formation, supporting the hypothesis that Pax6 acts cell-autonomously on NE progenitors cell cycle. Notably, these in vitro data correlated with aberrant numbers of mitosis observed in the optic vesicle of early stage Pax6 mutants, with Pax6 association with the chromatin upstream of p27kip1 promoter region, and with reduced expression levels of p27kip1, p57kip2, and p21cip1 in the primitive forebrain of Pax6 mutants. Taken together, our results suggest that, prior to retinal progenitor cell identity and neurogenesis, Pax6 is required to regulate the proliferation rate of NE progenitors present in the mouse optic vesicle." @default.
- W2019561816 created "2016-06-24" @default.
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- W2019561816 date "2007-01-01" @default.
- W2019561816 modified "2023-10-02" @default.
- W2019561816 title "Pax6 controls the proliferation rate of neuroepithelial progenitors from the mouse optic vesicle" @default.
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- W2019561816 doi "https://doi.org/10.1016/j.ydbio.2006.11.006" @default.
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