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- W2019562393 abstract "Effector T lymphocytes are the progeny of a limited number of antigen-specific precursor cells and it has been estimated that clonotypic human T cells may expand million fold on their way reaching high cell numbers that are sufficient for immune protection. Moreover, memory T cell responses are characterized by repetitive expansion of antigen-specific T cell clonotypes, and limitations in the proliferative capacity could lead to immune senescence. Because telomeres progressively shorten as a function of cell division, telomere length is a powerful indicator of the replicative in vivo history of human T lymphocytes. In this review, we summarize observations made over the last decade on telomere length dynamics of well-defined T cell populations derived from healthy donors and patients with infectious disease or cancer. We focus on T cell differentiation, T cell ageing, and natural and vaccine induced immune responses. We also discuss the scientific evidence for in vivo replicative senescence of antigen-specific T cells, and evaluate the available methods for measuring telomere lengths and telomerase activity, and their potential and limitations to increase our understanding of T cell physiology." @default.
- W2019562393 created "2016-06-24" @default.
- W2019562393 creator A5039372767 @default.
- W2019562393 creator A5049523087 @default.
- W2019562393 creator A5079146691 @default.
- W2019562393 date "2008-01-01" @default.
- W2019562393 modified "2023-09-23" @default.
- W2019562393 title "Assessing ageing of individual T lymphocytes: Mission impossible?" @default.
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