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• W2019571961 abstract "miR-155 is a prominent microRNA (miRNA) that regulates genes involved in immunity and cancer-related pathways. miR-155 is overexpressed in lung cancer, which correlates with poor patient prognosis. It is unclear how miR-155 becomes increased in lung cancers and how this increase contributes to reduced patient survival. Here, we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target, FOXO3A. Furthermore, we find that increased levels of miR-155 radioprotects lung cancer cells, while inhibition of miR-155 radiosensitizes these cells. Moreover, we reveal a therapeutically important link between miR-155 expression, hypoxia, and irradiation by demonstrating that anti-miR-155 molecules also sensitize hypoxic lung cancer cells to irradiation. Our study helps explain how miR-155 becomes elevated in lung cancers, which contain extensive hypoxic microenvironments, and demonstrates that inhibition of miR-155 may have important therapeutic potential as a means to radiosensitize hypoxic lung cancer cells." @default.
• W2019571961 created "2016-06-24" @default.
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• W2019571961 date "2011-11-15" @default.
• W2019571961 modified "2023-10-02" @default.
• W2019571961 title "Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells" @default.
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• W2019571961 doi "https://doi.org/10.4161/cbt.12.10.17681" @default.
• W2019571961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280906" @default.
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