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• W2019572015 abstract "Histamine induces a Th2 shift. As successful allopregnancy is characterized by a peripheral Th2 dominance, we investigated the role of histamine in reproduction.HDC knockout (HDC-/-) or wild-type (HDC+/+) mice kept on histamine-deficient or normal diet were mated. Appearance of vaginal plugs indicated day 0.5 of pregnancy. On day 10.5 uteri were inspected. Splenic IFN-gamma production and cytotoxic activity were determined.In HDC+/+ or HDC-/- females on normal diet, plugs appeared between 3 and 6 days. In 80% of the (HDC-/-)/(HDC-/-) matings on histamine-deficient diet, no vaginal plugs were observed for more than 1 month. After replacing males with the wild type, plugs appeared within 3 days. In HDC-/- mice, litter size was lower than in HDC+/+ animals. Cytotoxicity and IFN-gamma production were significantly increased in non-pregnant histamine-deficient mice, but not in pregnant mice.Histamine affects male mating behavior, but is not indispensable for successful pregnancy." @default.
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• W2019572015 date "2003-07-07" @default.
• W2019572015 modified "2023-10-14" @default.
• W2019572015 title "Impaired Reproduction of Histamine Deficient (histidine-decarboxylase Knockout) Mice is Caused Predominantly by a Decreased Male Mating Behavior" @default.
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• W2019572015 doi "https://doi.org/10.1034/j.1600-0897.2003.00066.x" @default.
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