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• W2019573055 endingPage "7215" @default.
• W2019573055 startingPage "7210" @default.
• W2019573055 abstract "During reverse transcription of retroviral RNA, synthesis of (−) strand DNA is primed by a cellular tRNA that anneals to an 18-nt primer binding site within the 5′ long terminal repeat. For (+) strand synthesis using a (−) strand DNA template linked to the tRNA primer, only the first 18 nt of tRNA are replicated to regenerate the primer binding site, creating the (+) strand strong stop DNA intermediate and providing a 3′ terminus capable of strand transfer and further elongation. On model HIV templates that approximate the (−) strand linked to natural modified or synthetic unmodified tRNA 3 Lys , we find that a (+) strand strong stop intermediate of the proper length is generated only on templates containing the natural, modified tRNA 3 Lys , suggesting that a posttranscriptional modification provides the termination signal. In the presence of a recipient template, synthesis after strand transfer occurs only from intermediates generated from templates containing modified tRNA 3 Lys . Reverse transcriptase from Moloney murine leukemia virus and avian myoblastosis virus shows the same requirement for a modified tRNA 3 Lys template. Because all retroviral tRNA primers contain the same 1-methyl-A 58 modification, our results suggest that 1-methyl-A 58 is generally required for termination of replication 18 nt into the tRNA sequence, generating the (+) strand intermediate, strand transfer, and subsequent synthesis of the entire (+) strand. The possibility that the host methyl transferase responsible for methylating A 58 may provide a target for HIV chemotherapy is discussed." @default.
• W2019573055 created "2016-06-24" @default.
• W2019573055 creator A5005151768 @default.
• W2019573055 creator A5089767525 @default.
• W2019573055 date "1997-07-08" @default.
• W2019573055 modified "2023-09-23" @default.
• W2019573055 title "Posttranscriptional modification of retroviral primers is required for late stages of DNA replication" @default.
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• W2019573055 doi "https://doi.org/10.1073/pnas.94.14.7210" @default.
• W2019573055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/23794" @default.
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