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- W2019582654 endingPage "261" @default.
- W2019582654 startingPage "250" @default.
- W2019582654 abstract "n-3 Polyunsaturated fatty acids (PUFA) are considered to be authentic immunosuppressors and appear to exert beneficial effects with respect to certain immune-mediated diseases. In addition to promoting T-helper 1 (Th1) cell to T-helper 2 (Th2) cell effector T-cell differentiation, n-3 PUFA may also exert anti-inflammatory actions by inducing apoptosis in Th1 cells. With respect to mechanisms of action, effects range from the modulation of membrane receptors to gene transcription via perturbation of a number of second messenger cascades. In this review, the putative targets of anti-inflammatory n-3 PUFA, activated during early and late events of T-cell activation will be discussed. Studies have demonstrated that these fatty acids alter plasma membrane micro-organization (lipid rafts) at the immunological synapse, the site where T-cells and antigen-presenting cells (APC) form a physical contact for antigen initiated T-cell signaling. In addition, the production of diacylglycerol and the activation of different isoforms of protein kinase C (PKC), mitogen-activated protein kinase (MAPK), calcium signaling, and nuclear translocation/activation of transcriptional factors, can be modulated by n-3 PUFA. Advantages and limitations of diverse methodologies to study the membrane lipid raft hypothesis, as well as apparent contradictions regarding the effect of n-3 PUFA on lipid rafts will be critically presented." @default.
- W2019582654 created "2016-06-24" @default.
- W2019582654 creator A5019568866 @default.
- W2019582654 creator A5024187649 @default.
- W2019582654 creator A5029447954 @default.
- W2019582654 creator A5052140012 @default.
- W2019582654 creator A5055539539 @default.
- W2019582654 creator A5087183337 @default.
- W2019582654 date "2010-07-01" @default.
- W2019582654 modified "2023-10-17" @default.
- W2019582654 title "Regulatory activity of polyunsaturated fatty acids in T-cell signaling" @default.
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