Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019594552> ?p ?o ?g. }
- W2019594552 endingPage "4300" @default.
- W2019594552 startingPage "4291" @default.
- W2019594552 abstract "Abstract The DEAH helicase RHAU (alias DHX36, G4R1) is the only helicase shown to have G-quadruplex (G4)–RNA resolvase activity and the major source of G4-DNA resolvase activity. Previous report showed RHAU mRNA expression to be elevated in human lymphoid and CD34+ BM cells, suggesting a potential role in hematopoiesis. Here, we generated a conditional knockout of the RHAU gene in mice. Germ line deletion of RHAU led to embryonic lethality. We then targeted the RHAU gene specifically in the hematopoiesis system, using a Cre-inducible system in which an optimized variant of Cre recombinase was expressed under the control of the Vav1 promoter. RHAU deletion in hematopoietic system caused hemolytic anemia and differentiation defect at the proerythroblast stage. The partial differentiation block of proerythroblasts was because of a proliferation defect. Transcriptome analysis of RHAU knockout proerythroblasts showed that a statistically significant portion of the deregulated genes contain G4 motifs in their promoters. This suggests that RHAU may play a role in the regulation of gene expression that relies on its G4 resolvase activity." @default.
- W2019594552 created "2016-06-24" @default.
- W2019594552 creator A5006262637 @default.
- W2019594552 creator A5015381965 @default.
- W2019594552 creator A5029803555 @default.
- W2019594552 creator A5040021029 @default.
- W2019594552 creator A5050358937 @default.
- W2019594552 creator A5065461897 @default.
- W2019594552 creator A5077535856 @default.
- W2019594552 date "2012-05-03" @default.
- W2019594552 modified "2023-10-03" @default.
- W2019594552 title "The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis" @default.
- W2019594552 cites W1917287502 @default.
- W2019594552 cites W1964541343 @default.
- W2019594552 cites W1970809104 @default.
- W2019594552 cites W1973387539 @default.
- W2019594552 cites W1989344540 @default.
- W2019594552 cites W1990635146 @default.
- W2019594552 cites W1991616035 @default.
- W2019594552 cites W1992564866 @default.
- W2019594552 cites W1993656252 @default.
- W2019594552 cites W2002817805 @default.
- W2019594552 cites W2010599622 @default.
- W2019594552 cites W2011824034 @default.
- W2019594552 cites W2015870397 @default.
- W2019594552 cites W2026370504 @default.
- W2019594552 cites W2033740694 @default.
- W2019594552 cites W2037978116 @default.
- W2019594552 cites W2038929178 @default.
- W2019594552 cites W2040806859 @default.
- W2019594552 cites W2041737563 @default.
- W2019594552 cites W2051848082 @default.
- W2019594552 cites W2055427321 @default.
- W2019594552 cites W2061837158 @default.
- W2019594552 cites W2067133520 @default.
- W2019594552 cites W2074271812 @default.
- W2019594552 cites W2076153728 @default.
- W2019594552 cites W2076812266 @default.
- W2019594552 cites W2080661557 @default.
- W2019594552 cites W2081056759 @default.
- W2019594552 cites W2091571816 @default.
- W2019594552 cites W2092238715 @default.
- W2019594552 cites W2103291845 @default.
- W2019594552 cites W2104752637 @default.
- W2019594552 cites W2110522968 @default.
- W2019594552 cites W2112001822 @default.
- W2019594552 cites W2117848662 @default.
- W2019594552 cites W2118097954 @default.
- W2019594552 cites W2122141896 @default.
- W2019594552 cites W2124938115 @default.
- W2019594552 cites W2126312758 @default.
- W2019594552 cites W2132222969 @default.
- W2019594552 cites W2146706147 @default.
- W2019594552 cites W2156056868 @default.
- W2019594552 cites W2156602474 @default.
- W2019594552 cites W2158937668 @default.
- W2019594552 cites W2159089297 @default.
- W2019594552 cites W2164683872 @default.
- W2019594552 doi "https://doi.org/10.1182/blood-2011-08-362954" @default.
- W2019594552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22422825" @default.
- W2019594552 hasPublicationYear "2012" @default.
- W2019594552 type Work @default.
- W2019594552 sameAs 2019594552 @default.
- W2019594552 citedByCount "42" @default.
- W2019594552 countsByYear W20195945522014 @default.
- W2019594552 countsByYear W20195945522015 @default.
- W2019594552 countsByYear W20195945522016 @default.
- W2019594552 countsByYear W20195945522017 @default.
- W2019594552 countsByYear W20195945522018 @default.
- W2019594552 countsByYear W20195945522019 @default.
- W2019594552 countsByYear W20195945522020 @default.
- W2019594552 countsByYear W20195945522021 @default.
- W2019594552 countsByYear W20195945522022 @default.
- W2019594552 countsByYear W20195945522023 @default.
- W2019594552 crossrefType "journal-article" @default.
- W2019594552 hasAuthorship W2019594552A5006262637 @default.
- W2019594552 hasAuthorship W2019594552A5015381965 @default.
- W2019594552 hasAuthorship W2019594552A5029803555 @default.
- W2019594552 hasAuthorship W2019594552A5040021029 @default.
- W2019594552 hasAuthorship W2019594552A5050358937 @default.
- W2019594552 hasAuthorship W2019594552A5065461897 @default.
- W2019594552 hasAuthorship W2019594552A5077535856 @default.
- W2019594552 hasBestOaLocation W20195945521 @default.
- W2019594552 hasConcept C104317684 @default.
- W2019594552 hasConcept C109159458 @default.
- W2019594552 hasConcept C153911025 @default.
- W2019594552 hasConcept C161223559 @default.
- W2019594552 hasConcept C173396325 @default.
- W2019594552 hasConcept C190232843 @default.
- W2019594552 hasConcept C28328180 @default.
- W2019594552 hasConcept C54355233 @default.
- W2019594552 hasConcept C67705224 @default.
- W2019594552 hasConcept C68592252 @default.
- W2019594552 hasConcept C86803240 @default.
- W2019594552 hasConcept C95444343 @default.
- W2019594552 hasConceptScore W2019594552C104317684 @default.
- W2019594552 hasConceptScore W2019594552C109159458 @default.
- W2019594552 hasConceptScore W2019594552C153911025 @default.