FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019600249> ?p ?o ?g. }

• W2019600249 endingPage "175" @default.
• W2019600249 startingPage "165" @default.
• W2019600249 abstract "The shutoff of active intermediates in the phototransduction cascade and the reconstitution of the visual pigment play key roles in the recovery of sensitivity after the exposure to bright light in both rod and cone photoreceptors. Physiological evidence from bleached salamander rods suggests this recovery of sensitivity occurs faster at the outer segment base compared with the tip. Microfluorometric measurements of similarly bleached salamander rods demonstrate that the reduction of all-trans retinal to all-trans retinol also occurs more rapidly at the outer segment base than at the tip. The experiments reported here were designed to test the hypothesis that these two phenomena are linked, e.g., that slowed recovery of sensitivity at the tip of outer segments is rate limited by the reduction of all-trans retinal and results from a shortage of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH), the reducing agent for all-trans retinal reduction. Extracellular measurements of membrane current and sensitivity were made from isolated salamander rods under dark-adapted and bleached conditions while intracellular NADPH concentration was varied by dialysis from a micropipette attached to the inner segment. Sensitivity at the base and tip of the outer segment was assessed before and after bleaching. After exposure to a light that photoactivates 50% of the visual pigment, rods were completely insensitive for nearly 10 minutes, after which the base recovered sensitivity and responsiveness with a time constant of approximately 200 seconds, but tip sensitivity recovered more slowly with a time constant of approximately 680 seconds. Dialysis of 5 mM NADPH into the rod promoted an earlier recovery and eliminated the previously observed tip/base difference. Dialysis of 1.66 mM NADPH failed to eliminate the tip/base recovery difference, suggesting the steady-state NADPH concentration in rods is approximately 1 mM. These results indicate the inner segment is the primary source of reducing equivalents after pigment bleaching, with the reduction of all-trans retinal to all-trans retinol playing a key step in the recovery of sensitivity." @default.
• W2019600249 created "2016-06-24" @default.
• W2019600249 creator A5011305143 @default.
• W2019600249 creator A5035273727 @default.
• W2019600249 creator A5080833504 @default.
• W2019600249 date "2009-08-17" @default.
• W2019600249 modified "2023-10-02" @default.
• W2019600249 title "Metabolic constraints on the recovery of sensitivity after visual pigment bleaching in retinal rods" @default.
• W2019600249 cites W140921251 @default.
• W2019600249 cites W1518778093 @default.
• W2019600249 cites W1571434023 @default.
• W2019600249 cites W1591442573 @default.
• W2019600249 cites W1965219715 @default.
• W2019600249 cites W1969358879 @default.
• W2019600249 cites W1975250798 @default.
• W2019600249 cites W1993606042 @default.
• W2019600249 cites W1994172606 @default.
• W2019600249 cites W2000310941 @default.
• W2019600249 cites W2001526908 @default.
• W2019600249 cites W2019431014 @default.
• W2019600249 cites W2035330651 @default.
• W2019600249 cites W2044439880 @default.
• W2019600249 cites W2044627868 @default.
• W2019600249 cites W2054508286 @default.
• W2019600249 cites W2054950142 @default.
• W2019600249 cites W2054982182 @default.
• W2019600249 cites W2056231114 @default.
• W2019600249 cites W2086546231 @default.
• W2019600249 cites W2098201185 @default.
• W2019600249 cites W2101853131 @default.
• W2019600249 cites W2113128166 @default.
• W2019600249 cites W2122261574 @default.
• W2019600249 cites W2128848159 @default.
• W2019600249 cites W2137331743 @default.
• W2019600249 cites W2141087826 @default.
• W2019600249 cites W2145213776 @default.
• W2019600249 cites W2153508944 @default.
• W2019600249 cites W2157476693 @default.
• W2019600249 cites W2419377376 @default.
• W2019600249 doi "https://doi.org/10.1085/jgp.200910267" @default.
• W2019600249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2737229" @default.
• W2019600249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19687232" @default.
• W2019600249 hasPublicationYear "2009" @default.
• W2019600249 type Work @default.
• W2019600249 sameAs 2019600249 @default.
• W2019600249 citedByCount "11" @default.
• W2019600249 countsByYear W20196002492012 @default.
• W2019600249 countsByYear W20196002492013 @default.
• W2019600249 countsByYear W20196002492016 @default.
• W2019600249 countsByYear W20196002492017 @default.
• W2019600249 countsByYear W20196002492020 @default.
• W2019600249 countsByYear W20196002492022 @default.
• W2019600249 countsByYear W20196002492023 @default.
• W2019600249 crossrefType "journal-article" @default.
• W2019600249 hasAuthorship W2019600249A5011305143 @default.
• W2019600249 hasAuthorship W2019600249A5035273727 @default.
• W2019600249 hasAuthorship W2019600249A5080833504 @default.
• W2019600249 hasBestOaLocation W20196002491 @default.
• W2019600249 hasConcept C105702510 @default.
• W2019600249 hasConcept C12554922 @default.
• W2019600249 hasConcept C131667965 @default.
• W2019600249 hasConcept C147789679 @default.
• W2019600249 hasConcept C151552171 @default.
• W2019600249 hasConcept C169760540 @default.
• W2019600249 hasConcept C178790620 @default.
• W2019600249 hasConcept C185592680 @default.
• W2019600249 hasConcept C2777093970 @default.
• W2019600249 hasConcept C2780827179 @default.
• W2019600249 hasConcept C43617362 @default.
• W2019600249 hasConcept C55493867 @default.
• W2019600249 hasConcept C64584667 @default.
• W2019600249 hasConcept C86803240 @default.
• W2019600249 hasConceptScore W2019600249C105702510 @default.
• W2019600249 hasConceptScore W2019600249C12554922 @default.
• W2019600249 hasConceptScore W2019600249C131667965 @default.
• W2019600249 hasConceptScore W2019600249C147789679 @default.
• W2019600249 hasConceptScore W2019600249C151552171 @default.
• W2019600249 hasConceptScore W2019600249C169760540 @default.
• W2019600249 hasConceptScore W2019600249C178790620 @default.
• W2019600249 hasConceptScore W2019600249C185592680 @default.
• W2019600249 hasConceptScore W2019600249C2777093970 @default.
• W2019600249 hasConceptScore W2019600249C2780827179 @default.
• W2019600249 hasConceptScore W2019600249C43617362 @default.
• W2019600249 hasConceptScore W2019600249C55493867 @default.
• W2019600249 hasConceptScore W2019600249C64584667 @default.
• W2019600249 hasConceptScore W2019600249C86803240 @default.
• W2019600249 hasIssue "3" @default.
• W2019600249 hasLocation W20196002491 @default.
• W2019600249 hasLocation W20196002492 @default.
• W2019600249 hasLocation W20196002493 @default.
• W2019600249 hasLocation W20196002494 @default.
• W2019600249 hasLocation W20196002495 @default.
• W2019600249 hasOpenAccess W2019600249 @default.
• W2019600249 hasPrimaryLocation W20196002491 @default.
• W2019600249 hasRelatedWork W1565011663 @default.
• W2019600249 hasRelatedWork W2019351429 @default.
• W2019600249 hasRelatedWork W2159128306 @default.
• W2019600249 hasRelatedWork W2402345182 @default.

• next