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- W2019607031 abstract "Recent advances in knowledge about the relation of divison delay to dose invalidate Lea's linear model of the recovery process. Since the present evidence is that delay is a straight-line function of dose, the first model considered is one postulating zero-order recovery kinetics. Although this yields a straight-line delay/dose relation, it is inconsistent in other respects. Lea's first-order model is reexamined and shown to lead to a logarithmic delay/dose relation which fails to fit the data for synchronized cell populations. A model is next considered in which the rate of recovery depends on the amount of uninjured biosynthetic substances remaining after irradiation. This model leads to second-order kinetics and a logistic recovery function. It is shown that this model yields a straight-line delay/dose relation and consistent estimates of the injury and recovery parameters. This second-order model is fitted to data for mammalian cells in culture and for vegetative division of Paramecium aurelia. The mo..." @default.
- W2019607031 created "2016-06-24" @default.
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- W2019607031 date "1968-03-01" @default.
- W2019607031 modified "2023-09-25" @default.
- W2019607031 title "Mathematical Analysis of the Division Delay Produced by Ionizing Radiations" @default.
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- W2019607031 doi "https://doi.org/10.2307/3572420" @default.
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