Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019610369> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2019610369 endingPage "6" @default.
- W2019610369 startingPage "2512" @default.
- W2019610369 abstract "Several beta-blockers have now been shown to be effective in reducing total mortality during the extended recovery period after myocardial infarction. The rate of occurrence of reinfarction and sudden death is also reduced. While the exact mechanisms of this beneficial effect are unknown, it appears to result from a class effect, ie, secondary to beta-blockade, since neither cardioselectivity, intrinsic sympathomimetic activity, nor membrane-stabilizing activity appears to be requisite. The reduction in mortality is seen in all age groups, for all types of infarction, and in all risk groups. On the basis of presently available evidence, in patients without contraindication to beta-blockade, prophylactic treatment with beta-blockers should be initiated between one and four weeks after myocardial infarction. The dosage should be sufficient to blunt the heart rate response to exercise, and therapy should be continued for at least two years. The positive results of several well-designed and conducted studies have proved that the concept of secondary prevention is a valid one and should help to save thousands of lives in the coming decade. It is expected that ongoing investigations will determine the efficacy and safety of earlier institution of beta-blockade, including IV administration in the peri-infarction period. The effectiveness of secondary prevention with other agents, including calcium channel blockers, antiplatelet agents, anticoagulants, lipid-lowering drugs, antiarrhythmics, prostacyclin analogues, and thromboxane synthetase inhibitors, should be investigated further. Additional information is needed on the mechanisms by which beta-blockers reduce mortality, sudden death, and reinfarction, on whether specific beta-blockers and/or specific types of beta-blockers have the greatest benefit, and, as a result of further analysis from some of the studies already published, the effect of beta-blockade after myocardial infarction on angina, rhythm disturbances, lipid profile abnormalities, and the quality of life." @default.
- W2019610369 created "2016-06-24" @default.
- W2019610369 creator A5022267024 @default.
- W2019610369 creator A5073895005 @default.
- W2019610369 date "1983-05-13" @default.
- W2019610369 modified "2023-10-17" @default.
- W2019610369 title "The use of beta-blockers after myocardial infarction." @default.
- W2019610369 cites W1514939306 @default.
- W2019610369 cites W1563600411 @default.
- W2019610369 cites W1978316819 @default.
- W2019610369 cites W1980531737 @default.
- W2019610369 cites W1980902536 @default.
- W2019610369 cites W1984595407 @default.
- W2019610369 cites W2024431059 @default.
- W2019610369 cites W2027885466 @default.
- W2019610369 cites W2043511280 @default.
- W2019610369 cites W2094152303 @default.
- W2019610369 cites W2159180233 @default.
- W2019610369 cites W578526946 @default.
- W2019610369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6133014" @default.
- W2019610369 hasPublicationYear "1983" @default.
- W2019610369 type Work @default.
- W2019610369 sameAs 2019610369 @default.
- W2019610369 citedByCount "15" @default.
- W2019610369 countsByYear W20196103692017 @default.
- W2019610369 countsByYear W20196103692018 @default.
- W2019610369 countsByYear W20196103692021 @default.
- W2019610369 crossrefType "journal-article" @default.
- W2019610369 hasAuthorship W2019610369A5022267024 @default.
- W2019610369 hasAuthorship W2019610369A5073895005 @default.
- W2019610369 hasConcept C126322002 @default.
- W2019610369 hasConcept C142724271 @default.
- W2019610369 hasConcept C164705383 @default.
- W2019610369 hasConcept C170493617 @default.
- W2019610369 hasConcept C199360897 @default.
- W2019610369 hasConcept C204787440 @default.
- W2019610369 hasConcept C2776174256 @default.
- W2019610369 hasConcept C2776494729 @default.
- W2019610369 hasConcept C2776663762 @default.
- W2019610369 hasConcept C2777798775 @default.
- W2019610369 hasConcept C2778151854 @default.
- W2019610369 hasConcept C2778468042 @default.
- W2019610369 hasConcept C2993353509 @default.
- W2019610369 hasConcept C41008148 @default.
- W2019610369 hasConcept C500558357 @default.
- W2019610369 hasConcept C71924100 @default.
- W2019610369 hasConceptScore W2019610369C126322002 @default.
- W2019610369 hasConceptScore W2019610369C142724271 @default.
- W2019610369 hasConceptScore W2019610369C164705383 @default.
- W2019610369 hasConceptScore W2019610369C170493617 @default.
- W2019610369 hasConceptScore W2019610369C199360897 @default.
- W2019610369 hasConceptScore W2019610369C204787440 @default.
- W2019610369 hasConceptScore W2019610369C2776174256 @default.
- W2019610369 hasConceptScore W2019610369C2776494729 @default.
- W2019610369 hasConceptScore W2019610369C2776663762 @default.
- W2019610369 hasConceptScore W2019610369C2777798775 @default.
- W2019610369 hasConceptScore W2019610369C2778151854 @default.
- W2019610369 hasConceptScore W2019610369C2778468042 @default.
- W2019610369 hasConceptScore W2019610369C2993353509 @default.
- W2019610369 hasConceptScore W2019610369C41008148 @default.
- W2019610369 hasConceptScore W2019610369C500558357 @default.
- W2019610369 hasConceptScore W2019610369C71924100 @default.
- W2019610369 hasIssue "18" @default.
- W2019610369 hasLocation W20196103691 @default.
- W2019610369 hasOpenAccess W2019610369 @default.
- W2019610369 hasPrimaryLocation W20196103691 @default.
- W2019610369 hasRelatedWork W1985513997 @default.
- W2019610369 hasRelatedWork W1991923555 @default.
- W2019610369 hasRelatedWork W2019610369 @default.
- W2019610369 hasRelatedWork W2031831008 @default.
- W2019610369 hasRelatedWork W2062689453 @default.
- W2019610369 hasRelatedWork W2081340494 @default.
- W2019610369 hasRelatedWork W2389112432 @default.
- W2019610369 hasRelatedWork W2411409993 @default.
- W2019610369 hasRelatedWork W2416185750 @default.
- W2019610369 hasRelatedWork W2911729115 @default.
- W2019610369 hasVolume "249" @default.
- W2019610369 isParatext "false" @default.
- W2019610369 isRetracted "false" @default.
- W2019610369 magId "2019610369" @default.
- W2019610369 workType "article" @default.