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- W2019614295 abstract "The RNA extracted from normal peritoneal macrophages exposed to a linear, random synthetic polypeptide, Glu(60)Ala(30)Tyr(10), initiated an immune response in C57B1/6J mice, although this strain responds very poorly to the antigen itself. From 10 to 150 micrograms of RNA obtained from mouse, rat, or rabbit macrophages was injected intraperitoneally into recipient mice, and specific antibody was detectable by passive hemagglutination 3 to 4 weeks later. Treatment of the RNA with ribonuclease destroyed its ability to initiate a specific immune response. The RNA contained by weight 0.02 percent of the (specific) antigen. The RNA obtained from cells incubated with a second polypeptide, Glu(36)Lys(24)Ala(40), initiated a response specific for this polymer. This RNA even when incubated in vitro with Glu(60)Ala(30)Tyr(10) failed to initiate antibody formation specific for Glu(60)Ala(30)Tyr(10)." @default.
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- W2019614295 date "1968-04-12" @default.
- W2019614295 modified "2023-09-26" @default.
- W2019614295 title "Antibody Formation: Initiation in Nonresponder Mice by Macrophage Synthetic Polypeptide RNA" @default.
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- W2019614295 doi "https://doi.org/10.1126/science.160.3824.194" @default.
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