FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019616830> ?p ?o ?g. }

• W2019616830 endingPage "11627" @default.
• W2019616830 startingPage "11621" @default.
• W2019616830 abstract "ABSTRACT Despite the reported efficacy of commercially available influenza virus vaccines, a considerable proportion of the human population does not respond well to vaccination. In an attempt to improve the immunogenicity of live influenza vaccines, an attenuated, cold-adapted ( ca ) influenza A virus expressing human interleukin-2 (IL-2) from the NS gene was generated. Intranasal immunization of young adult and aged mice with the IL-2-expressing virus resulted in markedly enhanced mucosal and cellular immune responses compared to those of mice immunized with the nonrecombinant ca parent strain. Interestingly, the mucosal immunoglobulin A (IgA) and CD8 + T-cell responses in the respiratory compartment could be restored in aged mice primed with the IL-2-expressing virus to magnitudes similar to those in young adult mice. The immunomodulating effect of locally expressed IL-2 also gave rise to a systemic CD8 + T-cell and distant urogenital IgA response in young adult mice, but this effect was less distinct in aged mice. Importantly, only mice immunized with the recombinant IL-2 virus were completely protected from a pathogenic wild-type virus challenge and revealed a stronger onset of virus-specific CD8 + T-cell recall response. Our findings emphasize the potential of reverse genetics to improve the efficacy of live influenza vaccines, thus rendering them more suitable for high-risk age groups." @default.
• W2019616830 created "2016-06-24" @default.
• W2019616830 creator A5006694993 @default.
• W2019616830 creator A5020100053 @default.
• W2019616830 creator A5022716555 @default.
• W2019616830 creator A5040263244 @default.
• W2019616830 creator A5057067822 @default.
• W2019616830 creator A5057236500 @default.
• W2019616830 date "2006-12-01" @default.
• W2019616830 modified "2023-09-23" @default.
• W2019616830 title "Live Attenuated Influenza Virus Expressing Human Interleukin-2 Reveals Increased Immunogenic Potential in Young and Aged Hosts" @default.
• W2019616830 cites W144653276 @default.
• W2019616830 cites W1494509082 @default.
• W2019616830 cites W1508567407 @default.
• W2019616830 cites W1513969932 @default.
• W2019616830 cites W1542481339 @default.
• W2019616830 cites W1578519055 @default.
• W2019616830 cites W1618733816 @default.
• W2019616830 cites W1840633113 @default.
• W2019616830 cites W1969276730 @default.
• W2019616830 cites W1971179964 @default.
• W2019616830 cites W1992479402 @default.
• W2019616830 cites W1994742954 @default.
• W2019616830 cites W1996982700 @default.
• W2019616830 cites W1997025461 @default.
• W2019616830 cites W2000363291 @default.
• W2019616830 cites W2002712477 @default.
• W2019616830 cites W2007244605 @default.
• W2019616830 cites W2013704309 @default.
• W2019616830 cites W2021101853 @default.
• W2019616830 cites W2023402775 @default.
• W2019616830 cites W2023534522 @default.
• W2019616830 cites W2024323589 @default.
• W2019616830 cites W2029465014 @default.
• W2019616830 cites W2036596307 @default.
• W2019616830 cites W2037682316 @default.
• W2019616830 cites W2043175663 @default.
• W2019616830 cites W2045118520 @default.
• W2019616830 cites W2049387979 @default.
• W2019616830 cites W2051066193 @default.
• W2019616830 cites W2051690374 @default.
• W2019616830 cites W2056095352 @default.
• W2019616830 cites W2056522394 @default.
• W2019616830 cites W2056666273 @default.
• W2019616830 cites W2064558980 @default.
• W2019616830 cites W2070343911 @default.
• W2019616830 cites W2071322149 @default.
• W2019616830 cites W2074885782 @default.
• W2019616830 cites W2077133851 @default.
• W2019616830 cites W2077332396 @default.
• W2019616830 cites W2077640158 @default.
• W2019616830 cites W2077877646 @default.
• W2019616830 cites W2078172887 @default.
• W2019616830 cites W2091080683 @default.
• W2019616830 cites W2094712265 @default.
• W2019616830 cites W2095044543 @default.
• W2019616830 cites W2096205389 @default.
• W2019616830 cites W2098292021 @default.
• W2019616830 cites W2101179800 @default.
• W2019616830 cites W2104444360 @default.
• W2019616830 cites W2114142573 @default.
• W2019616830 cites W2143153889 @default.
• W2019616830 cites W2144894027 @default.
• W2019616830 cites W2146389912 @default.
• W2019616830 cites W2148793959 @default.
• W2019616830 cites W2151778974 @default.
• W2019616830 cites W2152670961 @default.
• W2019616830 cites W2159482672 @default.
• W2019616830 cites W2161521034 @default.
• W2019616830 cites W2162336526 @default.
• W2019616830 cites W2164953394 @default.
• W2019616830 cites W2170408138 @default.
• W2019616830 cites W2318325499 @default.
• W2019616830 cites W2320976250 @default.
• W2019616830 cites W2326305272 @default.
• W2019616830 cites W2396878270 @default.
• W2019616830 cites W289288500 @default.
• W2019616830 cites W4251947800 @default.
• W2019616830 doi "https://doi.org/10.1128/jvi.01645-06" @default.
• W2019616830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1642586" @default.
• W2019616830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16971432" @default.
• W2019616830 hasPublicationYear "2006" @default.
• W2019616830 type Work @default.
• W2019616830 sameAs 2019616830 @default.
• W2019616830 citedByCount "32" @default.
• W2019616830 countsByYear W20196168302012 @default.
• W2019616830 countsByYear W20196168302013 @default.
• W2019616830 countsByYear W20196168302014 @default.
• W2019616830 countsByYear W20196168302015 @default.
• W2019616830 countsByYear W20196168302017 @default.
• W2019616830 countsByYear W20196168302019 @default.
• W2019616830 countsByYear W20196168302021 @default.
• W2019616830 countsByYear W20196168302023 @default.
• W2019616830 crossrefType "journal-article" @default.
• W2019616830 hasAuthorship W2019616830A5006694993 @default.
• W2019616830 hasAuthorship W2019616830A5020100053 @default.
• W2019616830 hasAuthorship W2019616830A5022716555 @default.
• W2019616830 hasAuthorship W2019616830A5040263244 @default.

• next