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- W2019617678 endingPage "1114" @default.
- W2019617678 startingPage "1106" @default.
- W2019617678 abstract "Electron spin resonance (ESR) spectroscopy has been used to investigate free radical generation in rats with acute methanol poisoning. The spin trapping technique was used where a spin trapping agent, α-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), reacted with the corresponding alcohol-derived or alcohol-dependent radical to form radical adducts. One radical adduct was detected in both bile and urine samples 2 h after acute methanol poisoning in male Sprague Dawley rats. The hyperfine coupling constants for the radical adduct from [13C]-labeled methanol detected in the bile were aN = 15.58, aβH = 2.81 G, and aβ13C = 4.53 G, which unambiguously identified this species as POBN/CH2OH. The same radical adduct was detected in urine. The identification of a methanol-derived radical adduct in samples from bile and urine provided strong direct evidence for the generation of the alcohol-derived radicals during acute intoxication by methanol. Simultaneous administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole and methanol resulted in an increase in the generation of the free radical metabolite detected in the bile. This is the first ESR evidence of methanol-derived free radical generation in an animal model of acute methanol intoxication." @default.
- W2019617678 created "2016-06-24" @default.
- W2019617678 creator A5015414029 @default.
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- W2019617678 date "2000-04-01" @default.
- W2019617678 modified "2023-09-23" @default.
- W2019617678 title "Acute methanol intoxication generates free radicals in rats: an ESR spin trapping investigation" @default.
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- W2019617678 doi "https://doi.org/10.1016/s0891-5849(00)00203-3" @default.
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