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- W2019620912 abstract "Lysine specific demethylase 1 (LSD1) plays a key role in the regulation of gene expression by removing the methyl groups from methylated Lys4 of histone H3 (H3K4). Here we report the identification of the first small-molecule LSD1-selective inhibitors. These inhibitors show in vivo H3K4-methylating activity and antiproliferative activity and should be useful as lead structures for anticancer drugs and as tools for studying the biological roles of LSD1." @default.
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- W2019620912 date "2009-11-16" @default.
- W2019620912 modified "2023-10-06" @default.
- W2019620912 title "Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors" @default.
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- W2019620912 doi "https://doi.org/10.1021/ja907055q" @default.
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