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• W2019624719 endingPage "39682" @default.
• W2019624719 startingPage "39675" @default.
• W2019624719 abstract "Steroid hormone receptors (SHRs) and nuclear receptors (NRs) in general are flexible, allosterically regulated transcription factors. The classic model is inadequate to explain all their behavior. Keys to function are their regions of intrinsic disorder (ID). Data show the dynamic structure and allosteric interactions of the three classic SHR domains: ligand-binding (LBD), DNA-binding (DBD), and N-terminal (NTD). Each responds to its ligands by stabilizing its structure. The LBD responds to classic steroidal and nonsteroidal small ligands; both may selectively modify SHR activity. The DBD responds differentially to the DNA sequences of its response elements. The NTD, with its high ID content and AF1, interacts allosterically with the LBD and DBD. Each domain binds heterologous proteins, potential allosteric ligands. An ensemble framework improves the classic model, shows how ID regions poise the SHR/NR family for optimal allosteric response, and provides a basis for quantitative evaluation of SHR/NR actions. Steroid hormone receptors (SHRs) and nuclear receptors (NRs) in general are flexible, allosterically regulated transcription factors. The classic model is inadequate to explain all their behavior. Keys to function are their regions of intrinsic disorder (ID). Data show the dynamic structure and allosteric interactions of the three classic SHR domains: ligand-binding (LBD), DNA-binding (DBD), and N-terminal (NTD). Each responds to its ligands by stabilizing its structure. The LBD responds to classic steroidal and nonsteroidal small ligands; both may selectively modify SHR activity. The DBD responds differentially to the DNA sequences of its response elements. The NTD, with its high ID content and AF1, interacts allosterically with the LBD and DBD. Each domain binds heterologous proteins, potential allosteric ligands. An ensemble framework improves the classic model, shows how ID regions poise the SHR/NR family for optimal allosteric response, and provides a basis for quantitative evaluation of SHR/NR actions." @default.
• W2019624719 created "2016-06-24" @default.
• W2019624719 creator A5006537594 @default.
• W2019624719 creator A5023619981 @default.
• W2019624719 date "2011-11-01" @default.
• W2019624719 modified "2023-10-18" @default.
• W2019624719 title "Structural Dynamics, Intrinsic Disorder, and Allostery in Nuclear Receptors as Transcription Factors" @default.
• W2019624719 cites W142850513 @default.
• W2019624719 cites W1569540889 @default.
• W2019624719 cites W1632044028 @default.
• W2019624719 cites W1965127482 @default.
• W2019624719 cites W1966229762 @default.
• W2019624719 cites W1967894996 @default.
• W2019624719 cites W1971555231 @default.
• W2019624719 cites W1971803615 @default.
• W2019624719 cites W1971943180 @default.
• W2019624719 cites W1973539026 @default.
• W2019624719 cites W1974572107 @default.
• W2019624719 cites W1975271726 @default.
• W2019624719 cites W1976430096 @default.
• W2019624719 cites W1985865142 @default.
• W2019624719 cites W1991430905 @default.
• W2019624719 cites W1991531351 @default.
• W2019624719 cites W1997856170 @default.
• W2019624719 cites W1997868107 @default.
• W2019624719 cites W1998105880 @default.
• W2019624719 cites W1999466810 @default.
• W2019624719 cites W1999738495 @default.
• W2019624719 cites W2002734029 @default.
• W2019624719 cites W2002991724 @default.
• W2019624719 cites W2006445814 @default.
• W2019624719 cites W2008354621 @default.
• W2019624719 cites W2010764705 @default.
• W2019624719 cites W2011983814 @default.
• W2019624719 cites W2012324003 @default.
• W2019624719 cites W2013837963 @default.
• W2019624719 cites W2017745978 @default.
• W2019624719 cites W2019429351 @default.
• W2019624719 cites W2023487073 @default.
• W2019624719 cites W2024900394 @default.
• W2019624719 cites W2025760262 @default.
• W2019624719 cites W2025919590 @default.
• W2019624719 cites W2027149291 @default.
• W2019624719 cites W2027309027 @default.
• W2019624719 cites W2027677896 @default.
• W2019624719 cites W2028605407 @default.
• W2019624719 cites W2029989251 @default.
• W2019624719 cites W2030914006 @default.
• W2019624719 cites W2032340987 @default.
• W2019624719 cites W2033911877 @default.
• W2019624719 cites W2036703508 @default.
• W2019624719 cites W2040556559 @default.
• W2019624719 cites W2041570934 @default.
• W2019624719 cites W2044915892 @default.
• W2019624719 cites W2046745425 @default.
• W2019624719 cites W2046886830 @default.
• W2019624719 cites W2048537273 @default.
• W2019624719 cites W2050767998 @default.
• W2019624719 cites W2052606462 @default.
• W2019624719 cites W2053528957 @default.
• W2019624719 cites W2059792018 @default.
• W2019624719 cites W2061674718 @default.
• W2019624719 cites W2066093213 @default.
• W2019624719 cites W2069141366 @default.
• W2019624719 cites W2070496155 @default.
• W2019624719 cites W2073290339 @default.
• W2019624719 cites W2074522426 @default.
• W2019624719 cites W2076165083 @default.
• W2019624719 cites W2079633900 @default.
• W2019624719 cites W2081170384 @default.
• W2019624719 cites W2082221765 @default.
• W2019624719 cites W2086260205 @default.
• W2019624719 cites W2087395511 @default.
• W2019624719 cites W2090272634 @default.
• W2019624719 cites W2090448704 @default.
• W2019624719 cites W2090630809 @default.
• W2019624719 cites W2093067883 @default.
• W2019624719 cites W2094387882 @default.
• W2019624719 cites W2102827103 @default.
• W2019624719 cites W2104360623 @default.
• W2019624719 cites W2107651677 @default.
• W2019624719 cites W2112444654 @default.
• W2019624719 cites W2116397033 @default.
• W2019624719 cites W2121454015 @default.
• W2019624719 cites W2132185105 @default.
• W2019624719 cites W2133833261 @default.
• W2019624719 cites W2137327729 @default.
• W2019624719 cites W2143462761 @default.
• W2019624719 cites W2145150473 @default.
• W2019624719 cites W2147610376 @default.
• W2019624719 cites W2149472608 @default.
• W2019624719 cites W2150228320 @default.
• W2019624719 cites W2150488741 @default.
• W2019624719 cites W2156034684 @default.
• W2019624719 cites W2158127085 @default.
• W2019624719 cites W2159865859 @default.
• W2019624719 cites W2164999339 @default.
• W2019624719 cites W2169670549 @default.

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