Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019627346> ?p ?o ?g. }
- W2019627346 endingPage "1221.e13" @default.
- W2019627346 startingPage "1221.e7" @default.
- W2019627346 abstract "Amyotrophic lateral sclerosis (ALS) is a heritable neurological disease for which the underlying genetic etiology is only partially understood. In Ireland, 83%–90% of cases are currently unexplained. Through large international collaborations, genome-wide association studies (GWASs) have succeeded in identifying a number of genomic loci that contribute toward ALS risk and age at onset. However, for the large proportion of risk that remains unexplained, population specificity of pathogenic variants could interfere with the detection of disease-associated loci. Single-population studies are therefore an important complement to larger international collaborations. In this study, we conduct a GWAS for ALS risk and age at onset in a large Irish ALS case-control cohort, using genome-wide imputation to increase marker density. Despite being adequately powered to detect associations of modest effect size, the study did not identify any locus associated with ALS risk or age at onset above the genome-wide significance threshold. Several speculative associations were, however, identified at loci that have been previously implicated in ALS. The lack of any clear association supports the conclusion that ALS is likely to be caused by multiple rare genetic risk factors. The findings of the present study highlight the importance of ongoing genetic research into the cause of ALS and its likely future challenges." @default.
- W2019627346 created "2016-06-24" @default.
- W2019627346 creator A5005110481 @default.
- W2019627346 creator A5019951034 @default.
- W2019627346 creator A5027753317 @default.
- W2019627346 creator A5030609927 @default.
- W2019627346 creator A5044622117 @default.
- W2019627346 creator A5057078027 @default.
- W2019627346 creator A5064379299 @default.
- W2019627346 creator A5073088894 @default.
- W2019627346 creator A5085491288 @default.
- W2019627346 date "2015-02-01" @default.
- W2019627346 modified "2023-09-25" @default.
- W2019627346 title "A second-generation Irish genome-wide association study for amyotrophic lateral sclerosis" @default.
- W2019627346 cites W1608778639 @default.
- W2019627346 cites W1963943740 @default.
- W2019627346 cites W1963948469 @default.
- W2019627346 cites W1964177214 @default.
- W2019627346 cites W1968068652 @default.
- W2019627346 cites W1973820967 @default.
- W2019627346 cites W1975262530 @default.
- W2019627346 cites W1992436001 @default.
- W2019627346 cites W2018886595 @default.
- W2019627346 cites W2020865850 @default.
- W2019627346 cites W2034225169 @default.
- W2019627346 cites W2040547343 @default.
- W2019627346 cites W2076404202 @default.
- W2019627346 cites W2077318431 @default.
- W2019627346 cites W2078866524 @default.
- W2019627346 cites W2080090138 @default.
- W2019627346 cites W2080802641 @default.
- W2019627346 cites W2087841974 @default.
- W2019627346 cites W2096140674 @default.
- W2019627346 cites W2096791516 @default.
- W2019627346 cites W2101486850 @default.
- W2019627346 cites W2104442834 @default.
- W2019627346 cites W2108169091 @default.
- W2019627346 cites W2111307685 @default.
- W2019627346 cites W2112265511 @default.
- W2019627346 cites W2116149846 @default.
- W2019627346 cites W2116982426 @default.
- W2019627346 cites W2126133831 @default.
- W2019627346 cites W2127034229 @default.
- W2019627346 cites W2137341875 @default.
- W2019627346 cites W2141645735 @default.
- W2019627346 cites W2151518318 @default.
- W2019627346 cites W2153600047 @default.
- W2019627346 cites W2157562219 @default.
- W2019627346 cites W2161633633 @default.
- W2019627346 cites W2164073493 @default.
- W2019627346 doi "https://doi.org/10.1016/j.neurobiolaging.2014.08.030" @default.
- W2019627346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25442119" @default.
- W2019627346 hasPublicationYear "2015" @default.
- W2019627346 type Work @default.
- W2019627346 sameAs 2019627346 @default.
- W2019627346 citedByCount "9" @default.
- W2019627346 countsByYear W20196273462016 @default.
- W2019627346 countsByYear W20196273462017 @default.
- W2019627346 countsByYear W20196273462019 @default.
- W2019627346 countsByYear W20196273462020 @default.
- W2019627346 countsByYear W20196273462022 @default.
- W2019627346 crossrefType "journal-article" @default.
- W2019627346 hasAuthorship W2019627346A5005110481 @default.
- W2019627346 hasAuthorship W2019627346A5019951034 @default.
- W2019627346 hasAuthorship W2019627346A5027753317 @default.
- W2019627346 hasAuthorship W2019627346A5030609927 @default.
- W2019627346 hasAuthorship W2019627346A5044622117 @default.
- W2019627346 hasAuthorship W2019627346A5057078027 @default.
- W2019627346 hasAuthorship W2019627346A5064379299 @default.
- W2019627346 hasAuthorship W2019627346A5073088894 @default.
- W2019627346 hasAuthorship W2019627346A5085491288 @default.
- W2019627346 hasConcept C104317684 @default.
- W2019627346 hasConcept C106208931 @default.
- W2019627346 hasConcept C119857082 @default.
- W2019627346 hasConcept C135763542 @default.
- W2019627346 hasConcept C137627325 @default.
- W2019627346 hasConcept C142724271 @default.
- W2019627346 hasConcept C153209595 @default.
- W2019627346 hasConcept C166252455 @default.
- W2019627346 hasConcept C180754005 @default.
- W2019627346 hasConcept C186413461 @default.
- W2019627346 hasConcept C2777898937 @default.
- W2019627346 hasConcept C2779134260 @default.
- W2019627346 hasConcept C2780596555 @default.
- W2019627346 hasConcept C2908647359 @default.
- W2019627346 hasConcept C41008148 @default.
- W2019627346 hasConcept C54355233 @default.
- W2019627346 hasConcept C58041806 @default.
- W2019627346 hasConcept C71924100 @default.
- W2019627346 hasConcept C86803240 @default.
- W2019627346 hasConcept C9357733 @default.
- W2019627346 hasConcept C99454951 @default.
- W2019627346 hasConceptScore W2019627346C104317684 @default.
- W2019627346 hasConceptScore W2019627346C106208931 @default.
- W2019627346 hasConceptScore W2019627346C119857082 @default.
- W2019627346 hasConceptScore W2019627346C135763542 @default.
- W2019627346 hasConceptScore W2019627346C137627325 @default.
- W2019627346 hasConceptScore W2019627346C142724271 @default.