Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019632472> ?p ?o ?g. }
- W2019632472 endingPage "626" @default.
- W2019632472 startingPage "616" @default.
- W2019632472 abstract "Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively and whether there is a direct link between this and the propensity for the sustained use of morphine to result in both tolerance and dependence has been studied intensely. Although frequently described as a partial agonist, this characteristic appears insufficient to explain the poor capacity of morphine to promote internalisation of the mu opioid receptor. Experiments performed using both transfected cell systems and ex vivo/in vivo models have provided evidence that when morphine can promote internalisation of the mu receptor there is a decrease in the development of tolerance and dependence. Although aspects of this model are controversial, such observations suggest a number of approaches to further enhance the use of morphine as an analgesic. Keywords: morphine, tolerance, dependence, receptor internalisation, desensitization" @default.
- W2019632472 created "2016-06-24" @default.
- W2019632472 creator A5045597067 @default.
- W2019632472 creator A5051585961 @default.
- W2019632472 date "2010-11-01" @default.
- W2019632472 modified "2023-10-16" @default.
- W2019632472 title "Opioid Regulation of Mu Receptor Internalisation: Relevance to the Development of Tolerance and Dependence" @default.
- W2019632472 cites W1492294380 @default.
- W2019632472 cites W1529268309 @default.
- W2019632472 cites W1598320815 @default.
- W2019632472 cites W1655589213 @default.
- W2019632472 cites W1858569662 @default.
- W2019632472 cites W1933410007 @default.
- W2019632472 cites W1966464596 @default.
- W2019632472 cites W1967208942 @default.
- W2019632472 cites W1967760715 @default.
- W2019632472 cites W1972198700 @default.
- W2019632472 cites W1976479743 @default.
- W2019632472 cites W1977269379 @default.
- W2019632472 cites W1978667645 @default.
- W2019632472 cites W1981501355 @default.
- W2019632472 cites W1984377490 @default.
- W2019632472 cites W1986447940 @default.
- W2019632472 cites W1986906801 @default.
- W2019632472 cites W2004120139 @default.
- W2019632472 cites W2008935385 @default.
- W2019632472 cites W2012438218 @default.
- W2019632472 cites W2015087988 @default.
- W2019632472 cites W2015200229 @default.
- W2019632472 cites W2018610067 @default.
- W2019632472 cites W2022337168 @default.
- W2019632472 cites W2023079553 @default.
- W2019632472 cites W2030209219 @default.
- W2019632472 cites W2032568216 @default.
- W2019632472 cites W2033111233 @default.
- W2019632472 cites W2042097750 @default.
- W2019632472 cites W2042801541 @default.
- W2019632472 cites W2043944866 @default.
- W2019632472 cites W2044240689 @default.
- W2019632472 cites W2051746492 @default.
- W2019632472 cites W2058101038 @default.
- W2019632472 cites W2058246949 @default.
- W2019632472 cites W2064008986 @default.
- W2019632472 cites W2064734596 @default.
- W2019632472 cites W2070610920 @default.
- W2019632472 cites W2072681884 @default.
- W2019632472 cites W2073554097 @default.
- W2019632472 cites W2075722147 @default.
- W2019632472 cites W2080815758 @default.
- W2019632472 cites W2082667221 @default.
- W2019632472 cites W2083071923 @default.
- W2019632472 cites W2084721137 @default.
- W2019632472 cites W2088359192 @default.
- W2019632472 cites W2090232288 @default.
- W2019632472 cites W2095742540 @default.
- W2019632472 cites W2095996466 @default.
- W2019632472 cites W2097882590 @default.
- W2019632472 cites W2109083102 @default.
- W2019632472 cites W2110807916 @default.
- W2019632472 cites W2117762969 @default.
- W2019632472 cites W2118579624 @default.
- W2019632472 cites W2119339974 @default.
- W2019632472 cites W2120701014 @default.
- W2019632472 cites W2124507412 @default.
- W2019632472 cites W2126059273 @default.
- W2019632472 cites W2127424619 @default.
- W2019632472 cites W2127846911 @default.
- W2019632472 cites W2138158469 @default.
- W2019632472 cites W2155088506 @default.
- W2019632472 cites W2163268436 @default.
- W2019632472 cites W2163352150 @default.
- W2019632472 cites W2163804310 @default.
- W2019632472 cites W2169996576 @default.
- W2019632472 cites W2172734677 @default.
- W2019632472 cites W2341523955 @default.
- W2019632472 doi "https://doi.org/10.2174/187152710793361522" @default.
- W2019632472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20632966" @default.
- W2019632472 hasPublicationYear "2010" @default.
- W2019632472 type Work @default.
- W2019632472 sameAs 2019632472 @default.
- W2019632472 citedByCount "10" @default.
- W2019632472 countsByYear W20196324722012 @default.
- W2019632472 countsByYear W20196324722014 @default.
- W2019632472 countsByYear W20196324722015 @default.
- W2019632472 countsByYear W20196324722016 @default.
- W2019632472 countsByYear W20196324722017 @default.
- W2019632472 countsByYear W20196324722020 @default.
- W2019632472 crossrefType "journal-article" @default.
- W2019632472 hasAuthorship W2019632472A5045597067 @default.
- W2019632472 hasAuthorship W2019632472A5051585961 @default.
- W2019632472 hasBestOaLocation W20196324722 @default.
- W2019632472 hasConcept C14397066 @default.
- W2019632472 hasConcept C150903083 @default.
- W2019632472 hasConcept C170493617 @default.
- W2019632472 hasConcept C185592680 @default.
- W2019632472 hasConcept C207001950 @default.
- W2019632472 hasConcept C2777389121 @default.
- W2019632472 hasConcept C2778938600 @default.