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- W2019637900 abstract "Abstract A 10‐hydroxycamptothecin‐encapsulated magnetic nanovehicle (HEMN) was fabricated by coencapsulating Fe 3 O 4 nanoparticles and 10‐hydroxycamptothecin (HCPT) into a micelle core self‐assembled from the amphiphilic copolymer methoxy‐poly(ethylene glycol)–poly( d,l ‐lactide‐co‐glycolide) through a facile dialysis method. A satisfactory drug‐loading content of (9.03±0.67) % and a relatively high encapsulation efficiency of (53.52±6.46) % were achieved. In vitro drug release was performed by membrane dialysis and a pH‐dependent release behavior was observed. In comparison with free HCPT dissolved in dimethylsulfoxide, HEMNs showed a greatly improved in vitro antitumor efficacy against three different human cancer cell lines—HeLa, A549, and HepG2—and lower IC 50 values were measured. The mechanism of cell death was investigated, and it was clearly demonstrated that the apoptosis process was triggered. An in vitro wound‐healing assay and a transwell assay indicated that HEMNs exerted much stronger activity in inhibiting HeLa cell migration. The cellular uptake of HEMNs in a desired area can be significantly enhanced by an external magnetic field. These results demonstrate HCPT‐encapsulated magnetic nanovehicles might have important potential in clinical applications for inhibiting tumor metastasis and for targeted drug delivery." @default.
- W2019637900 created "2016-06-24" @default.
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- W2019637900 date "2012-09-20" @default.
- W2019637900 modified "2023-10-18" @default.
- W2019637900 title "Enhanced In Vitro Antitumor Efficacy and Strong Anti-Cell-Migration Activity of a Hydroxycamptothecin-Encapsulated Magnetic Nanovehicle" @default.
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- W2019637900 doi "https://doi.org/10.1002/chem.201200765" @default.
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