FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019637954> ?p ?o ?g. }

• W2019637954 endingPage "1421" @default.
• W2019637954 startingPage "1407" @default.
• W2019637954 abstract "Myocardial adrenergic receptors (ARs) play important roles in cardiac hypertrophy. However, the detailed molecular mechanism of AR-mediated cardiac hypertrophy remains elusive to date. To gain full insight into how ARs are involved in the regulation of cardiac hypertrophy, protein expression profiling was performed with comparative proteomics approach on neonatal rat cardiomyocytes. Forty-six proteins were identified as differentially expressed in hypertrophic cardiomyocytes induced by AR stimulation. To better understand the biological significance of the obtained proteomic data, we utilized the ingenuity pathway analysis tool to construct biological networks and analyze function and pathways that might associate with AR-mediated cardiac hypertrophy. Pathway analysis strongly suggested that ROS may be involved in the development of AR-mediated cardiac hypertrophy, which was then confirmed by further experimentation. The results showed that a marked increase in ROS production was detected in AR-mediated cardiac hypertrophy and blocking of ROS production significantly inhibited AR-mediated cardiac hypertrophy. We further proved that the ROS production was through NADPH oxidase or the mitochondrial electron transport chain and this ROS accumulation resulted in activation of extracellular signal-regulated kinase 1/2 leading to AR-mediated cardiac hypertrophy. These experimental results support the hypothesis, from the ingenuity pathway analysis, that AR-mediated cardiac hypertrophy is associated with the dysregulation of a complicated oxidative stress-regulatory network. In conclusion, our results provide a basis for understanding the detailed molecular mechanisms of AR-mediated cardiac hypertrophy." @default.
• W2019637954 created "2016-06-24" @default.
• W2019637954 creator A5013463034 @default.
• W2019637954 creator A5018912965 @default.
• W2019637954 creator A5022244258 @default.
• W2019637954 creator A5032472866 @default.
• W2019637954 creator A5042627512 @default.
• W2019637954 creator A5055517335 @default.
• W2019637954 creator A5060341807 @default.
• W2019637954 creator A5064603337 @default.
• W2019637954 creator A5070425018 @default.
• W2019637954 creator A5075124906 @default.
• W2019637954 date "2009-10-13" @default.
• W2019637954 modified "2023-10-16" @default.
• W2019637954 title "Proteomic profiling reveals comprehensive insights into adrenergic receptor-mediated hypertrophy in neonatal rat cardiomyocytes" @default.
• W2019637954 cites W1501522779 @default.
• W2019637954 cites W1875111347 @default.
• W2019637954 cites W1971687277 @default.
• W2019637954 cites W1979003242 @default.
• W2019637954 cites W1986624071 @default.
• W2019637954 cites W1989355270 @default.
• W2019637954 cites W2013210006 @default.
• W2019637954 cites W2024206262 @default.
• W2019637954 cites W2026605955 @default.
• W2019637954 cites W2029543479 @default.
• W2019637954 cites W2050497715 @default.
• W2019637954 cites W2058014017 @default.
• W2019637954 cites W2059599014 @default.
• W2019637954 cites W2063449424 @default.
• W2019637954 cites W2078322631 @default.
• W2019637954 cites W2079532357 @default.
• W2019637954 cites W2082461149 @default.
• W2019637954 cites W2085812290 @default.
• W2019637954 cites W2086727917 @default.
• W2019637954 cites W2089279418 @default.
• W2019637954 cites W2093707863 @default.
• W2019637954 cites W2100541308 @default.
• W2019637954 cites W2102797065 @default.
• W2019637954 cites W2103668027 @default.
• W2019637954 cites W2105892074 @default.
• W2019637954 cites W2109331497 @default.
• W2019637954 cites W2110362194 @default.
• W2019637954 cites W2110508279 @default.
• W2019637954 cites W2110889457 @default.
• W2019637954 cites W2120655951 @default.
• W2019637954 cites W2121622875 @default.
• W2019637954 cites W2121735022 @default.
• W2019637954 cites W2123465814 @default.
• W2019637954 cites W2124860132 @default.
• W2019637954 cites W2129787950 @default.
• W2019637954 cites W2137082708 @default.
• W2019637954 cites W2150739709 @default.
• W2019637954 cites W2152142106 @default.
• W2019637954 cites W2152989188 @default.
• W2019637954 cites W2154020206 @default.
• W2019637954 cites W2159898309 @default.
• W2019637954 cites W2165807417 @default.
• W2019637954 cites W2167151063 @default.
• W2019637954 cites W2167955976 @default.
• W2019637954 cites W2581157121 @default.
• W2019637954 cites W4210960398 @default.
• W2019637954 cites W4242236756 @default.
• W2019637954 cites W4255946693 @default.
• W2019637954 doi "https://doi.org/10.1002/prca.200900029" @default.
• W2019637954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21136960" @default.
• W2019637954 hasPublicationYear "2009" @default.
• W2019637954 type Work @default.
• W2019637954 sameAs 2019637954 @default.
• W2019637954 citedByCount "6" @default.
• W2019637954 countsByYear W20196379542012 @default.
• W2019637954 countsByYear W20196379542013 @default.
• W2019637954 countsByYear W20196379542015 @default.
• W2019637954 countsByYear W20196379542016 @default.
• W2019637954 countsByYear W20196379542021 @default.
• W2019637954 crossrefType "journal-article" @default.
• W2019637954 hasAuthorship W2019637954A5013463034 @default.
• W2019637954 hasAuthorship W2019637954A5018912965 @default.
• W2019637954 hasAuthorship W2019637954A5022244258 @default.
• W2019637954 hasAuthorship W2019637954A5032472866 @default.
• W2019637954 hasAuthorship W2019637954A5042627512 @default.
• W2019637954 hasAuthorship W2019637954A5055517335 @default.
• W2019637954 hasAuthorship W2019637954A5060341807 @default.
• W2019637954 hasAuthorship W2019637954A5064603337 @default.
• W2019637954 hasAuthorship W2019637954A5070425018 @default.
• W2019637954 hasAuthorship W2019637954A5075124906 @default.
• W2019637954 hasConcept C126322002 @default.
• W2019637954 hasConcept C134018914 @default.
• W2019637954 hasConcept C167414201 @default.
• W2019637954 hasConcept C170493617 @default.
• W2019637954 hasConcept C2776151105 @default.
• W2019637954 hasConcept C62478195 @default.
• W2019637954 hasConcept C71924100 @default.
• W2019637954 hasConcept C86803240 @default.
• W2019637954 hasConcept C95444343 @default.
• W2019637954 hasConceptScore W2019637954C126322002 @default.
• W2019637954 hasConceptScore W2019637954C134018914 @default.
• W2019637954 hasConceptScore W2019637954C167414201 @default.
• W2019637954 hasConceptScore W2019637954C170493617 @default.

• next