FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019642959> ?p ?o ?g. }

• W2019642959 endingPage "1482" @default.
• W2019642959 startingPage "1473" @default.
• W2019642959 abstract "Oxidative stress and oxidative modification of biomolecules are involved in several physiological and pathophysiological processes. We have previously reported that Notopterygium forbesii Boiss (NF), a traditional Chinese medicine, and its active constituents, including phenethyl ferulate (PF), bergaptol, and isoimperatorin, induced oxidative stress with increased levels of reactive species and heme oxygenase-1 in human fetal hepatocytes. The current study determined the effects of NF and PF on the inflammatory effects of lipopolysaccharide (LPS). Exposure of RAW 264.7 macrophages to LPS increased the expression of inducible nitric oxide synthase and cyclooxygenase 2 and stimulated the formation of reactive nitrogen species. In a coculture system, the LPS-activated macrophages also induced expression of cell adhesion molecules (including E-selectin, intercellular cell adhesion molecule 1, and vascular cell adhesion molecule 1) in human umbilical vein endothelial cells (HUVEC) and vascular smooth muscle cells (VSMC). Preincubation of macrophages with NF or PF attenuated the effects of LPS on macrophages as well as their effects on HUVEC and VSMC. These inhibitory effects of NF and PF were decreased in the presence of N-acetyl-l-cysteine (NAC). At the same time, NAC also reduced NF- or PF-induced increases in reactive oxygen species (ROS) and Hsp32 protein levels and the formation of protein carbonyls in the macrophages. These results suggest that NF- or PF-induced ROS generation and oxidative modifications of intracellular proteins may be responsible for the inhibitory actions of NF and PF on LPS-induced inflammatory responses. These data add to the growing literature that ROS may sometimes be anti-inflammatory." @default.
• W2019642959 created "2016-06-24" @default.
• W2019642959 creator A5047168734 @default.
• W2019642959 creator A5053726981 @default.
• W2019642959 creator A5071314271 @default.
• W2019642959 creator A5088970715 @default.
• W2019642959 date "2009-07-31" @default.
• W2019642959 modified "2023-09-23" @default.
• W2019642959 title "<i>Notopterygium forbesii</i> Boiss Extract and Its Active Constituent Phenethyl Ferulate Attenuate Pro-Inflammatory Responses to Lipopolysaccharide in RAW 264.7 Macrophages. A “Protective” Role for Oxidative Stress?" @default.
• W2019642959 cites W1508162082 @default.
• W2019642959 cites W1535816350 @default.
• W2019642959 cites W1967315269 @default.
• W2019642959 cites W1970420221 @default.
• W2019642959 cites W1973632534 @default.
• W2019642959 cites W1977913875 @default.
• W2019642959 cites W1979125328 @default.
• W2019642959 cites W1984380214 @default.
• W2019642959 cites W1995317658 @default.
• W2019642959 cites W2000499892 @default.
• W2019642959 cites W2002907671 @default.
• W2019642959 cites W2009643591 @default.
• W2019642959 cites W2015794078 @default.
• W2019642959 cites W2016366656 @default.
• W2019642959 cites W2016587256 @default.
• W2019642959 cites W2020590566 @default.
• W2019642959 cites W2020600203 @default.
• W2019642959 cites W2021242983 @default.
• W2019642959 cites W2022466310 @default.
• W2019642959 cites W2023160229 @default.
• W2019642959 cites W2033761996 @default.
• W2019642959 cites W2058137293 @default.
• W2019642959 cites W2075428562 @default.
• W2019642959 cites W2085781412 @default.
• W2019642959 cites W2088936315 @default.
• W2019642959 cites W2091783295 @default.
• W2019642959 cites W2106015379 @default.
• W2019642959 cites W2106877484 @default.
• W2019642959 cites W2107095021 @default.
• W2019642959 cites W2108251074 @default.
• W2019642959 cites W2129242841 @default.
• W2019642959 cites W2134947892 @default.
• W2019642959 cites W2149790826 @default.
• W2019642959 cites W2151186546 @default.
• W2019642959 cites W2152746956 @default.
• W2019642959 cites W2162010936 @default.
• W2019642959 cites W2204123985 @default.
• W2019642959 cites W2325740861 @default.
• W2019642959 cites W4230693812 @default.
• W2019642959 cites W4313333645 @default.
• W2019642959 doi "https://doi.org/10.1021/tx900163h" @default.
• W2019642959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19642688" @default.
• W2019642959 hasPublicationYear "2009" @default.
• W2019642959 type Work @default.
• W2019642959 sameAs 2019642959 @default.
• W2019642959 citedByCount "12" @default.
• W2019642959 countsByYear W20196429592012 @default.
• W2019642959 countsByYear W20196429592014 @default.
• W2019642959 countsByYear W20196429592015 @default.
• W2019642959 countsByYear W20196429592017 @default.
• W2019642959 countsByYear W20196429592018 @default.
• W2019642959 countsByYear W20196429592019 @default.
• W2019642959 countsByYear W20196429592020 @default.
• W2019642959 crossrefType "journal-article" @default.
• W2019642959 hasAuthorship W2019642959A5047168734 @default.
• W2019642959 hasAuthorship W2019642959A5053726981 @default.
• W2019642959 hasAuthorship W2019642959A5071314271 @default.
• W2019642959 hasAuthorship W2019642959A5088970715 @default.
• W2019642959 hasConcept C16224149 @default.
• W2019642959 hasConcept C178790620 @default.
• W2019642959 hasConcept C185592680 @default.
• W2019642959 hasConcept C202751555 @default.
• W2019642959 hasConcept C203014093 @default.
• W2019642959 hasConcept C2776151105 @default.
• W2019642959 hasConcept C2776914184 @default.
• W2019642959 hasConcept C2777411675 @default.
• W2019642959 hasConcept C2778754761 @default.
• W2019642959 hasConcept C2779525624 @default.
• W2019642959 hasConcept C48349386 @default.
• W2019642959 hasConcept C519581460 @default.
• W2019642959 hasConcept C55493867 @default.
• W2019642959 hasConcept C57600042 @default.
• W2019642959 hasConcept C79879829 @default.
• W2019642959 hasConcept C86803240 @default.
• W2019642959 hasConcept C95444343 @default.
• W2019642959 hasConcept C98274493 @default.
• W2019642959 hasConceptScore W2019642959C16224149 @default.
• W2019642959 hasConceptScore W2019642959C178790620 @default.
• W2019642959 hasConceptScore W2019642959C185592680 @default.
• W2019642959 hasConceptScore W2019642959C202751555 @default.
• W2019642959 hasConceptScore W2019642959C203014093 @default.
• W2019642959 hasConceptScore W2019642959C2776151105 @default.
• W2019642959 hasConceptScore W2019642959C2776914184 @default.
• W2019642959 hasConceptScore W2019642959C2777411675 @default.
• W2019642959 hasConceptScore W2019642959C2778754761 @default.
• W2019642959 hasConceptScore W2019642959C2779525624 @default.
• W2019642959 hasConceptScore W2019642959C48349386 @default.
• W2019642959 hasConceptScore W2019642959C519581460 @default.
• W2019642959 hasConceptScore W2019642959C55493867 @default.

• next