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• W2019646743 startingPage "e1003400" @default.
• W2019646743 abstract "Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a critical role in inflammatory responses. The inflammasome activates caspase-1 to process and secrete IL-1β. However, the mechanisms governing IL-1α release are less clear. Recently, a non-canonical inflammasome was described that activates caspase-11 and mediates pyroptosis and release of IL-1α and IL-1β. Caspase-11 activation in response to Gram-negative bacteria requires Toll-like receptor 4 (TLR4) and TIR-domain-containing adaptor-inducing interferon-β (TRIF)-dependent interferon production. Whether additional bacterial signals trigger caspase-11 activation is unknown. Many bacterial pathogens use specialized secretion systems to translocate effector proteins into the cytosol of host cells. These secretion systems can also deliver flagellin into the cytosol, which triggers caspase-1 activation and pyroptosis. However, even in the absence of flagellin, these secretion systems induce inflammasome activation and the release of IL-1α and IL-1β, but the inflammasome pathways that mediate this response are unclear. We observe rapid IL-1α and IL-1β release and cell death in response to the type IV or type III secretion systems of Legionella pneumophila and Yersinia pseudotuberculosis. Unlike IL-1β, IL-1α secretion does not require caspase-1. Instead, caspase-11 activation is required for both IL-1α secretion and cell death in response to the activity of these secretion systems. Interestingly, whereas caspase-11 promotes IL-1β release in response to the type IV secretion system through the NLRP3/ASC inflammasome, caspase-11-dependent release of IL-1α is independent of both the NAIP5/NLRC4 and NLRP3/ASC inflammasomes as well as TRIF and type I interferon signaling. Furthermore, we find both overlapping and non-redundant roles for IL-1α and IL-1β in mediating neutrophil recruitment and bacterial clearance in response to pulmonary infection by L. pneumophila. Our findings demonstrate that virulent, but not avirulent, bacteria trigger a rapid caspase-11-dependent innate immune response important for host defense." @default.
• W2019646743 created "2016-06-24" @default.
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• W2019646743 date "2013-06-06" @default.
• W2019646743 modified "2023-10-14" @default.
• W2019646743 title "Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol" @default.
• W2019646743 cites W1529674879 @default.
• W2019646743 cites W1585737615 @default.
• W2019646743 cites W193754658 @default.
• W2019646743 cites W1964977785 @default.
• W2019646743 cites W1970935350 @default.
• W2019646743 cites W1971857640 @default.
• W2019646743 cites W1975032025 @default.
• W2019646743 cites W1978100320 @default.
• W2019646743 cites W1978231462 @default.
• W2019646743 cites W1981837371 @default.
• W2019646743 cites W1987463569 @default.
• W2019646743 cites W1988197452 @default.
• W2019646743 cites W1998585620 @default.
• W2019646743 cites W2004829503 @default.
• W2019646743 cites W2007747853 @default.
• W2019646743 cites W2008034134 @default.
• W2019646743 cites W2009004909 @default.
• W2019646743 cites W2009523990 @default.
• W2019646743 cites W2009800174 @default.
• W2019646743 cites W2012193854 @default.
• W2019646743 cites W2014602273 @default.
• W2019646743 cites W2016503643 @default.
• W2019646743 cites W2018271515 @default.
• W2019646743 cites W2023368253 @default.
• W2019646743 cites W2023478821 @default.
• W2019646743 cites W2024591203 @default.
• W2019646743 cites W2032773353 @default.
• W2019646743 cites W2032958179 @default.
• W2019646743 cites W2038143978 @default.
• W2019646743 cites W2042816890 @default.
• W2019646743 cites W2051658957 @default.
• W2019646743 cites W2055408817 @default.
• W2019646743 cites W2062436911 @default.
• W2019646743 cites W2065183886 @default.
• W2019646743 cites W2065330071 @default.
• W2019646743 cites W2066904343 @default.
• W2019646743 cites W2066974855 @default.
• W2019646743 cites W2069502810 @default.
• W2019646743 cites W2070597700 @default.
• W2019646743 cites W2074747472 @default.
• W2019646743 cites W2076063079 @default.
• W2019646743 cites W2079580539 @default.
• W2019646743 cites W2080827095 @default.
• W2019646743 cites W2081343476 @default.
• W2019646743 cites W2083859580 @default.
• W2019646743 cites W2084981002 @default.
• W2019646743 cites W2087616650 @default.
• W2019646743 cites W2089228242 @default.
• W2019646743 cites W2089664448 @default.
• W2019646743 cites W2090165838 @default.
• W2019646743 cites W2090859543 @default.
• W2019646743 cites W2094750535 @default.
• W2019646743 cites W2097072854 @default.
• W2019646743 cites W2097714951 @default.
• W2019646743 cites W2101141686 @default.
• W2019646743 cites W2105263387 @default.
• W2019646743 cites W2109315536 @default.
• W2019646743 cites W2109831629 @default.
• W2019646743 cites W2113485094 @default.
• W2019646743 cites W2113760809 @default.
• W2019646743 cites W2114216755 @default.
• W2019646743 cites W2114737175 @default.
• W2019646743 cites W2116577338 @default.
• W2019646743 cites W2116765105 @default.
• W2019646743 cites W2118800225 @default.
• W2019646743 cites W2119256241 @default.
• W2019646743 cites W2120815988 @default.
• W2019646743 cites W2123811305 @default.
• W2019646743 cites W2128190429 @default.
• W2019646743 cites W2129319176 @default.
• W2019646743 cites W2130421043 @default.
• W2019646743 cites W2132482634 @default.
• W2019646743 cites W2133449490 @default.
• W2019646743 cites W2139485450 @default.
• W2019646743 cites W2144467901 @default.
• W2019646743 cites W2149231090 @default.
• W2019646743 cites W2150594596 @default.
• W2019646743 cites W2155538302 @default.
• W2019646743 cites W2155795106 @default.
• W2019646743 cites W2157783137 @default.
• W2019646743 cites W2157883244 @default.
• W2019646743 cites W2161320421 @default.

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