FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019646912> ?p ?o ?g. }

• W2019646912 endingPage "2396" @default.
• W2019646912 startingPage "2385" @default.
• W2019646912 abstract "The interaction between neurosteroids and sigma1 (σ1) receptors may be of therapeutic interest during physiological or pathological ageing, particularly concerning their neuromodulatory role on cognitive functions. Neurosteroids modulate memory processes through a mechanism involving interactions with GABAA, N-methyl- d-aspartate and/or σ1 receptors. To measure the contribution of endogenous neurosteroid levels to the antiamnesic effects of σ1 agonists, we investigated the effects of inhibitors of key enzymes involved in neurosteroid synthesis, in adrenalectomized/castrated (AdX/CX) mice to avoid the effect of circulating steroids. Trilostane, a 3β-hydroxysteroid-deshydrogenase inhibitor, blocks the pregnenolone to progesterone conversion and leads to a decrease of progesterone. Finasteride, a 5α-reductase inhibitor, blocks the progesterone to 5α-pregnane-3,20-dione conversion and leads to an accumulation of progesterone. The in vivo binding of (+)-[3H]SKF-10 047 to σ1 sites was measured in the mouse hippocampus and cortex. The attenuating effect of the selective σ1 agonist PRE-084 (0.1–3 mg/kg) against dizocilpine (0.15 mg/kg)-induced learning impairment was examined using spontaneous alternation behaviour, step-down passive avoidance and place learning in the elevated plus-maze. The in vivo (+)-[3H]SKF-10 047 binding appeared significantly increased in AdX/CX mice and after trilostane treatment (10 mg/kg twice a day, 7 days), compared with sham-operated animals. The finasteride treatment (25 mg/kg, 7 days) significantly decreased binding levels. The learning deficits induced by dizocilpine were not affected by the treatments. The antiamnesic effect of PRE-084 was facilitated in AdX/CX mice and even more after trilostane treatment, as several parameters for animals treated with both PRE-084 and dizocilpine returned to control values. The PRE-084 effect was blocked after finasteride. These results confirmed that endogenous neurosteroidal levels modulate σ1 receptor-mediated behaviour directly, and revealed that, among neurosteroids, progesterone may be the main modulator of σ1 receptors." @default.
• W2019646912 created "2016-06-24" @default.
• W2019646912 creator A5045510832 @default.
• W2019646912 creator A5059647237 @default.
• W2019646912 creator A5063051115 @default.
• W2019646912 creator A5081275789 @default.
• W2019646912 date "1999-07-01" @default.
• W2019646912 modified "2023-10-04" @default.
• W2019646912 title "Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice" @default.
• W2019646912 cites W1487569549 @default.
• W2019646912 cites W1574849955 @default.
• W2019646912 cites W1611380972 @default.
• W2019646912 cites W1964651098 @default.
• W2019646912 cites W1965844174 @default.
• W2019646912 cites W1972869752 @default.
• W2019646912 cites W1976698562 @default.
• W2019646912 cites W1976917710 @default.
• W2019646912 cites W1981258864 @default.
• W2019646912 cites W1981475053 @default.
• W2019646912 cites W1984917548 @default.
• W2019646912 cites W1986787786 @default.
• W2019646912 cites W1988218442 @default.
• W2019646912 cites W1989507808 @default.
• W2019646912 cites W1992500239 @default.
• W2019646912 cites W1992768650 @default.
• W2019646912 cites W1993097947 @default.
• W2019646912 cites W1994224293 @default.
• W2019646912 cites W2001104167 @default.
• W2019646912 cites W2003524311 @default.
• W2019646912 cites W2003532781 @default.
• W2019646912 cites W2006283790 @default.
• W2019646912 cites W2008606615 @default.
• W2019646912 cites W2012757985 @default.
• W2019646912 cites W2014224549 @default.
• W2019646912 cites W2014823486 @default.
• W2019646912 cites W2020036669 @default.
• W2019646912 cites W2021663038 @default.
• W2019646912 cites W2023479166 @default.
• W2019646912 cites W2023900408 @default.
• W2019646912 cites W2024344189 @default.
• W2019646912 cites W2026692772 @default.
• W2019646912 cites W2028395596 @default.
• W2019646912 cites W2031211058 @default.
• W2019646912 cites W2031242571 @default.
• W2019646912 cites W2032914550 @default.
• W2019646912 cites W2037626982 @default.
• W2019646912 cites W2038360643 @default.
• W2019646912 cites W2040395804 @default.
• W2019646912 cites W2041587294 @default.
• W2019646912 cites W2042643556 @default.
• W2019646912 cites W2046877633 @default.
• W2019646912 cites W2048263472 @default.
• W2019646912 cites W2054597500 @default.
• W2019646912 cites W2055112994 @default.
• W2019646912 cites W2057830838 @default.
• W2019646912 cites W2062502420 @default.
• W2019646912 cites W2071059133 @default.
• W2019646912 cites W2073035026 @default.
• W2019646912 cites W2079590715 @default.
• W2019646912 cites W2083447043 @default.
• W2019646912 cites W2087495709 @default.
• W2019646912 cites W2088516321 @default.
• W2019646912 cites W2089379946 @default.
• W2019646912 cites W2090303341 @default.
• W2019646912 cites W2092190455 @default.
• W2019646912 cites W2128635872 @default.
• W2019646912 cites W2136498727 @default.
• W2019646912 cites W2144121773 @default.
• W2019646912 cites W2146164085 @default.
• W2019646912 cites W2166966506 @default.
• W2019646912 cites W4235744243 @default.
• W2019646912 cites W4245117662 @default.
• W2019646912 cites W4250923633 @default.
• W2019646912 doi "https://doi.org/10.1046/j.1460-9568.1999.00656.x" @default.
• W2019646912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10383628" @default.
• W2019646912 hasPublicationYear "1999" @default.
• W2019646912 type Work @default.
• W2019646912 sameAs 2019646912 @default.
• W2019646912 citedByCount "48" @default.
• W2019646912 countsByYear W20196469122012 @default.
• W2019646912 countsByYear W20196469122013 @default.
• W2019646912 countsByYear W20196469122015 @default.
• W2019646912 countsByYear W20196469122016 @default.
• W2019646912 countsByYear W20196469122017 @default.
• W2019646912 countsByYear W20196469122019 @default.
• W2019646912 countsByYear W20196469122022 @default.
• W2019646912 crossrefType "journal-article" @default.
• W2019646912 hasAuthorship W2019646912A5045510832 @default.
• W2019646912 hasAuthorship W2019646912A5059647237 @default.
• W2019646912 hasAuthorship W2019646912A5063051115 @default.
• W2019646912 hasAuthorship W2019646912A5081275789 @default.
• W2019646912 hasConcept C121608353 @default.
• W2019646912 hasConcept C126322002 @default.
• W2019646912 hasConcept C134018914 @default.
• W2019646912 hasConcept C168258287 @default.
• W2019646912 hasConcept C170493617 @default.
• W2019646912 hasConcept C178790620 @default.
• W2019646912 hasConcept C185592680 @default.

• next